Evidence map›Paper›PMID 40677225›Full record

Observational studyStroke2025

Biomarkers of Thromboelastography Platelet Mapping Predict Hematoma Expansion After Spontaneous Intracerebral Hemorrhage.

Kaleigh M Copenhaver, Juliana Silva Pinheiro do Nascimiento, Rajeev K Garg, Fernando D Goldenberg, Harish Shownkeen, Matthew B Potts, Babak S Jahromi, Paul F Lindholm, Andrew M Naidech

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaleigh M CopenhaverDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (K.M.C., J.S.P.N., A.M.N.).ORCID 0009-0004-0906-7161
Juliana Silva Pinheiro do NascimientoDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (K.M.C., J.S.P.N., A.M.N.).ORCID 0009-0000-4460-666X
Rajeev K GargDepartment of Neurological Sciences, Division of Neurocritical Care, Rush University Medical Center, Chicago, IL (R.K.G.).ORCID 0000-0002-1949-8019
Fernando D GoldenbergDivision of Neurocritical Care, Departments of Neurology and Neurosurgery, University of Chicago Medicine, IL (F.D.G.).ORCID 0000-0003-1100-6830
Harish ShownkeenComprehensive Stroke Center, Northwestern Medicine-Central DuPage Hospital, Winfield, IL (H.S.).
Matthew B PottsDepartment of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL (M.B.P., B.S.J.).ORCID 0000-0002-0534-5097
Babak S JahromiDepartment of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL (M.B.P., B.S.J.).ORCID 0000-0001-5064-5278
Paul F LindholmDivision of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Chicago, IL (P.F.L.).ORCID 0000-0003-2498-6372
Andrew M NaidechDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (K.M.C., J.S.P.N., A.M.N.).ORCID 0000-0003-1065-5417

Funding

Hemostasis, Hematoma Expansion, and Outcomes After Intracerebral HemorrhageR01NS110779 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAIDECH, ANDREW M · 2019 to 2023
$3.3M
NINDS NIH HHS R01 NS110779
6 · The paper itself

Abstract

backgroundHematoma expansion (HE) is a preventable cause of disability and death in patients with acute intracerebral hemorrhage (ICH). Platelet activity is essential for coagulation, and antiplatelet medications (eg, aspirin, clopidogrel) increase HE risk. General markers of platelet activity are associated with later HE, but specific biomarkers of platelet activity could enhance our understanding. We hypothesized that hemostatic biomarkers of platelet activity would correlate with later HE.

methodsWe conducted a tri-center observational cohort study of spontaneous ICH patients with multiple imaging scans for HE calculation. The thromboelastography 6s Platelet Mapping assay assessed platelet activity with 3 biomarkers: (1) adenosine diphosphate receptor-induced platelet activation, (2) platelet-fibrin network clot strength measured by heparinized kaolin with heparinase, and (3) fibrinogen-only clot strength measured by activator F (ActF). Spearman rank measured the correlation between HE and platelet activity. A linear regression model predicted HE from ActF. We tested whether the relationship between ActF and HE interacted with pre-ICH antiplatelet medication.

resultsThirty-five patients were included. Eleven (35.48%) took pre-ICH antiplatelet medication. Heparinized kaolin with heparinase negatively correlated with HE (

conclusionsHemostatic biomarkers from the thromboelastography 6s Platelet Mapping assay predicted subsequent HE and may aid in determining neurosurgical need. Strengthening platelet-mediated coagulation may be a target for reducing HE and improving ICH outcomes.

Indexed as

Blood PlateletsCerebral HemorrhageHematomaPlatelet ActivationThrombelastographyAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedPlatelet Aggregation InhibitorsBiomarkersPlatelet Aggregation Inhibitorsbiomarkersfibrinogenhematomaheparinplatelet activation

Identifiers

PMID40677225
PMCPMC12313221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.