Evidence map›Paper›PMID 40677115›Full record

ReviewChemistryOpen2025

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications.

Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y S Chau, Jonathan C Knowles, Feng Peng, Alessandro Poma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ren YangDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.
Xiaohan MaDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.
Mingcheng XuanKavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Rd, Oxford, OX1 3QU, UK.
Yingqi MaDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.
Jiexian DingThe Pediatric Orthopaedics, The Second Hospital of Lanzhou University, Lanzhou, 730030, China.
David Y S ChauDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.ORCID 0000-0001-9200-6749
Jonathan C KnowlesDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.ORCID 0000-0003-3917-3446
Feng PengDepartment of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.ORCID 0000-0003-2366-2253
Alessandro PomaDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.ORCID 0000-0003-2913-0389

Funding

Great Britain-China Educational TrustNational Institute for Health and Care ResearchRosetrees TrustRoyal Society of ChemistryUniversity College LondonWellcome TrustWellcome Trust ISSF3
6 · The paper itself

Abstract

This review explores the application of molecularly imprinted polymers (MIPs) in detecting bone turnover biomarkers and advancing osteogenic treatment strategies. MIPs, designed to mimic biological recognition sites, offer innovative solutions for precise molecular recognition in bone health management. Chemical methodologies for MIPs synthesis and their integration into diagnostic systems for detecting bone resorption markers are highlighted. Furthermore, MIP-driven therapeutic advancements, including controlled drug release, cell imprinting for osteogenic differentiation, and functional scaffolds for tissue regeneration, are emphasized. This review underscores MIPs' potential to revolutionize bone disease management and calls for further exploration into chemical designs to optimize their clinical and practical applications.

Indexed as

Molecularly Imprinted PolymersAnimalsBiomarkersHumansMolecular ImagingOsteogenesisBiomarkersMolecularly Imprinted Polymersbone biomarkerscontrolled drug releasemolecularly imprinted polymersosteogenic treatmenttissue engineering

Identifiers

PMID40677115
PMCPMC12598817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.