Rocket-Like Microneedle Patch for Sustained Hormone Therapy in Prostate Cancer.

Ying-Tzu Chen, Kuan-Ta Chen, Kai-Jie Yu, See-Tong Pang, Hung-Wei Yang

Abstract read

In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ying-Tzu ChenDepartment of Neurosurgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan.

Kuan-Ta ChenInstitute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.

Kai-Jie YuDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou Branch, Taoyuan 33305, Taiwan.

See-Tong PangDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou Branch, Taoyuan 33305, Taiwan.

Hung-Wei YangDepartment of Biomedical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-8438-6291

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) remains a significant global health challenge, necessitating the development of advanced therapeutic strategies. This study introduces a rocket-like microneedle patch (RLMNP) as a dual-layer drug delivery system for sustained hormone therapy in PCa. RLMNP integrates a rapid-release layer, employing the pH-responsive zeolitic imidazolate framework-8 (ZIF-8) to encapsulate bicalutamide (CDX), and a sustained-release layer comprising an alginate-tyramine (Alg-Tyr) hydrogel loaded with goserelin. The dual mechanism synergistically targets PCa by blocking androgen receptor signaling and suppressing androgen synthesis. RLMNP demonstrates robust mechanical properties, efficient skin penetration, and controlled drug release profiles.

Indexed as

AnilidesDrug Delivery SystemsGoserelinNitrilesProstatic NeoplasmsTosyl CompoundsAdministration, CutaneousAlginatesAnimalsCell Line, TumorDelayed-Action PreparationsDrug LiberationHumansHydrogelsMaleMiceAlginatesAnilidesbicalutamideDelayed-Action PreparationsGoserelinHydrogelsNitrilesTosyl CompoundsZeoliteshormone therapymicroneedle patch (MNP)prostate cancer (PCa)sustained drug releasezeolitic imidazolate framework-8 (ZIF-8)

Identifiers

PMID40676997

DOI10.1021/acsbiomaterials.5c00127

PMCPMC12344640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.