Observational studyJournal of the American Heart Association2025
Sex-Stratified Long-Term Outcome After Percutaneous Coronary Intervention: A Pooled Analysis of the SORT OUT All-Comer Trials.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, the sex-differentiated outcome after percutaneous coronary intervention (PCI) favors male sex in most studies. In this study, we aimed to investigate the age-adjusted impact of sex on long-term outcome.
methodsThe study was an observational, prospective, multicenter, cohort study with pooling of 5-year results of the randomized controlled all-comer stent trials SORT OUT (Scandinavian Organization for Randomized Trials With Clinical Outcome) III, V, VI, VII, VIII, and IX conducted from 2006 to 2017. All patients were followed for 5 years. The predefined main outcome was a major adverse cardiac event (MACE); a composite end point comprising all-cause death, spontaneous myocardial infarction, and target lesion revascularization assessed by a clinical event committee. MACE difference across sex was assessed by incidence rate ratios at 5 years adjusted for age and predefined risk factors.
resultsIn total, 15 242 patients (women, 3729 [24.5%]) with a mean age of 67.8±11.0 years were included in the study, with 0.2% lost to follow-up. Compared with men, women were older (women, 67.8±11.0 years; men, 64.8±10.7 years), had more hypertension and dyslipidemia but less previous MI and revascularization. MACEs occurred in 747 (21.8%) of the women and 2196 (20.5%) of the men at 5 years (unadjusted incidence rate ratio, 1.07 [95% CI, 0.98-1.16]; and adjusted incidence rate ratio, 0.91 [95% CI, 0.84-0.99]). Female sex was not associated with an increased risk in any of the individual MACE components.
conclusionsFemale sex was not associated with a poorer long-term outcome than male sex after treatment for coronary artery disease with percutaneous coronary intervention in MACEs or any of the individual components.
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