ArticleJournal of the American Heart Association2025
Association of Lipid Profile With Cardiovascular Diseases and All-Cause Death: A 2-Decade Follow-Up of the Tehran Lipid and Glucose Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cardiovascular Disease Mortality Events and Predictors in the Tehran Lipid and Glucose Study: A 20-Year Cohort Review .International journal of endocrinology and metabolism · 2026Review
- Association of Serum Lipids with 10-Year CVD and All-Cause Mortality in Iranian Adults: A Prospective Cohort Study.Archives of Iranian medicine · 2025Article
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3 authors.
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Abstract
backgroundWe investigated the associations between total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and triglycerides with all-cause and cardiovascular disease death among participants in the TLGS (Tehran Lipid and Glucose Study) cohort.
methodsWe included 8241 participants aged ≥30 years, who were followed until 2018. Lipid profiles were assessed as both continuous and categorical variables (quintiles) using the restricted cubic spline and Cox proportional hazards model.
resultsDuring a median follow-up of 18.1 years, 1002 and 369 individuals died from all causes and cardiovascular disease, respectively. A U-shaped association was found between non-HDL-C and the risk of all-cause death. In the categorical analyses for all-cause death, individuals in quintile 1 of non-HDL-C had a hazard ratio (HR) of 1.35 (95% CI, 1.09-1.68), compared with quintile 2 (reference). Additionally, those in quintiles 1 and 3 of total cholesterol had HRs of 1.34 (95% CI, 1.08-1.67) and 1.25 (95% CI, 1.02-1.55), respectively, relative to quintile 2 (reference). Regarding cardiovascular disease death, linear associations were observed for total cholesterol, low-density lipoprotein cholesterol, and non-HDL-C. In categorical analysis, quintiles 3 and 5 of total cholesterol had HRs of 1.87 (95% CI, 1.30-2.70) and 1.78 (95% CI, 1.25-2.53), respectively, compared with quintile 2 (reference). Furthermore, compared with quintile 1 of low-density lipoprotein cholesterol (reference), individuals in quintiles 3 and 5 had HRs of 1.62 (95% CI, 1.08-2.42) and 1.81 (95% CI, 1.24-2.66), respectively. For non-HDL-C, the HR for quintile 5 was 1.43 (95% CI, 1.00-2.06) compared with quintile 1 (reference).
conclusionsIn the general population, low and high levels of non-HDL-C were associated with an increased risk of all-cause death.
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