ArticleThe European journal of neuroscience2025
GSK-3β and mTOR Phosphorylation Mediate the Reversible Regulation of Hypomagnetic Field on Adult Neural Stem Cell Proliferation.
Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Mitochondria as key targets underlying hypomagnetic field-induced biological effects.iScience · 2026Review
- GSK-3β and mTOR Phosphorylation Mediate the Reversible Regulation of Hypomagnetic Field on Adult Neural Stem Cell Proliferation.The European journal of neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Exposure to hypomagnetic field (HMF) of < 5 μT has been demonstrated to impair cognitive behaviors in mammals by disrupting neurogenesis. This process could potentially be modulated by the protein phosphorylation of adult neural stem cells (aNSCs) that are highly sensitive to environmental changes. However, the effects of HMF on aNSCs protein phosphorylation remain unclear. Here, we found that HMF reversibly regulates the effects on aNSC proliferation by modulating protein phosphorylation in aNSCs. Specifically, HMF inhibits aNSCs proliferation by reducing glycogen synthase kinase 3β (GSK-3β) phosphorylation, and when aNSCs are returned from HMF to the geomagnetic field (rGMF), rGMF activates mammalian target of rapamycin (mTOR) phosphorylation to restore their proliferation. These findings not only advance our understanding of the molecular basis of HMF-induced biological effects but also illuminate potential therapeutic targets for maintaining neural homeostasis in extreme environments.
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Registered trials
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