ArticleParasites & vectors2025
Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- G protein-coupled receptor SmGPCR9 interacts with neuropeptides and controls spermatogenesis in Schistosoma mansoni.PLoS pathogens · 2026Article
- NResearch (Washington, D.C.) · 2026Article
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3 authors.
Funding
Abstract
backgroundSchistosomiasis is a zoonotic parasitic disease of the genus Schistosoma. Current therapeutic approaches predominantly rely on the single drug praziquantel, highlighting the urgent need to identify additional effective drug targets. G protein-coupled receptors (GPCRs) play important roles in various biological processes and are considered pivotal in drug development. However, the current understanding of the function of GPCRs in schistosomes remains limited.
methodsWe conducted a systematic bioinformatics analysis of Schistosoma japonicum GPCRs using public genomic resources to elucidate their molecular evolution and expression profiles. Selected GPCRs were functionally characterized using whole-mount in situ hybridization, double fluorescence in situ hybridization, and RNA interference.
resultsBioinformatics analysis identified 126 GPCR genes in S. japonicum and 8 GPCRs were selected for further studies. qPCR analyses revealed that EWB00_004787 (Sj-Smo) and EWB00_003955 (Sj-imGPCR) were significantly enriched in the vitellarium of female worms, where they were found to colocalize with Sj-DDR48. Following RNAi inhibition of Sj-Smo and Sj-imGPCR, cell proliferation in the vitellarium was significantly reduced by 73% and 54%, respectively, and egg productions were also markedly decreased.
conclusionsThis study identifies Sj-Smo and Sj-imGPCR as essential regulators of vitellarium development and egg production in S. japonicum. Targeting these GPCRs may represent a potentially promising strategy to disrupt egg-mediated pathology and transmission for schistosomiasis control.
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