Evidence map›Paper›PMID 40676657›Full record

ArticleProteome science2025

To explore the molecular mechanism of IRF7 involved in acute kidney injury in sepsis based on proteomics.

Li Xiang, Ma Wanli, Song Jiannan, Hu Zhanfei, Zhou Qi, Li Haibo

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Article in Proteome science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Li Xiang *Department of Anesthesiology, Inner Mongolia Autonomous Region, Chifeng Clinical College of Inner Mongolia Medical University, Chifeng, 024000, China.
Ma Wanli *Department of Anesthesiology, Municipal Hospital of Chifeng, Inner Mongolia Autonomous Region, Chifeng, 024000, China.
Song JiannanDepartment of Anesthesiology, Municipal Hospital of Chifeng, Inner Mongolia Autonomous Region, Chifeng, 024000, China.
Hu ZhanfeiDepartment of Anesthesiology, Municipal Hospital of Chifeng, Inner Mongolia Autonomous Region, Chifeng, 024000, China.
Zhou QiDepartment of Anesthesiology, Municipal Hospital of Chifeng, Inner Mongolia Autonomous Region, Chifeng, 024000, China. zhouqi1020818@sina.com.
Li HaiboDepartment of Anesthesiology, Municipal Hospital of Chifeng, Inner Mongolia Autonomous Region, Chifeng, 024000, China. 475857584@qq.com.

Funding

Inner Mongolia Natural Science Foundation 2022MS08001Inner Mongolia Natural Science Foundation 2023MS08036National Natural Science Fundation 82204895
6 · The paper itself

Abstract

backgroundAcute kidney injury is a common complication of sepsis, and its mechanism is very complicated. The purpose of this study was to investigate the mechanism of key differentially expressed proteins and their related signaling pathways in the occurrence and development of acute kidney injury in sepsis through proteomics.

methodsAcute kidney injury was induced by intraperitoneal injection of lipopolysaccharide at 10 mg/kg. Renal tissues were analyzed by TMT quantitative proteomic analysis. Differentially expressed proteins (DEPs) were screened. Gene Ontology (GO) function analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network analysis were performed.

resultsWe obtained 530 DEPs. GO analysis showed that the biological process of DEPs was mainly stress response. The molecular functions of DEPs mainly focus on catalytic activity. The cellular components of DEPs were mainly located in the intracellular and cytoplasm. KEGG analysis showed that DEPs were mainly involved in metabolic pathways. Ten key proteins with interaction degree, such as Isg15, Irf7, Oasl2, Ifit3, Apob, Oasl, Ube2l6, Ifit2, Ifih1 and Ifit1 were identified. Irf7 was significantly up-regulated in rat kidney tissues.

conclusionThe upregulation of Irf7 plays an important role in the mechanism of acute renal injury induced by sepsis.

Indexed as

Acute kidney injuryBioinformaticsIrf7ProteomicsSepsis

Identifiers

PMID40676657
PMCPMC12273476

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