ReviewBMC oral health2025
Silver diamine fluoride: the science behind the action - a narrative review.
Review in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Silver diamine fluoride versus atraumatic restorative treatment for management of childhood caries: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Knowledge, attitude and practice of paediatric dentists towards silver diammine fluoride in Egypt: a national survey.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Assessment of tannic acid and glutathione in 38% silver diamine fluoride for dentine stain reduction with antibacterial efficacy: AnBioinformation · 2026Article
- TheBiomaterial investigations in dentistry · 2026Article
- Effect of silver diamine fluoride versus fluoride varnish in arresting early childhood caries: A clinical study.Bioinformation · 2026Article
- Concept and techniques for minimal invasive restorative dentistry: A review.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilver Diamine Fluoride (SDF) is a caries-arresting agent that gained popularity among clinicians and patients due to its effectiveness within hours of application. However, the exact mechanisms underlying its action are not yet fully understood. This narrative review explores the current knowledge of SDF's role in caries management, focusing on its mechanism of action, application methods, and safety.
methodsA comprehensive search was conducted in PubMed, MEDLINE, ScienceDirect, and Google Scholar. Out of 820 identified studies, 40 were selected based on relevance to SDF's chemical properties and clinical application, following duplicate removal and screening of abstracts and full texts.
resultsAlthough the literature provides insight into SDF's benefits in managing caries, its exact mechanism of action and long-term outcomes remain insufficiently understood. Furthermore, variations in the composition of commercially available SDF products, particularly in silver, fluoride, and pH levels, may significantly affect their clinical performance. This variability raises concerns about consistency in therapeutic outcomes and underscores the need for formulation standardization.
conclusionUnderstanding SDF antimicrobial and remineralization mechanisms is essential for optimizing its clinical use in caries management. While current evidence supports its efficacy, further studies are needed to standardize formulations, refine application protocols, and clarify its long-term therapeutic outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.