Trial reportBMC anesthesiology2025
Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Correlation Study of Internal Jugular Vein Variability Under Deep Inhalation and Propofol-induced Hypotension
Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement：A Prospective, Randomized Controlled Study
Who cites it
2 citing papers in PubMed.
- Preventing intraoperative hypotension in propofol-sedated gastroenteroscopy: a randomized trial of crystalloid preloading.Surgical endoscopy · 2026Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundMethods for reliably predicting hypotension in patients during general anesthesia induction are currently lacking. Deep inhalation has been shown to enhance the variability of the internal jugular vein (IJV). In this study, we aim to investigate the relationship between internal jugular vein variability (IJVV) during deep inhalation and the extent of blood pressure decrease during propofol induction, as well as the potential of utilizing IJVV as a guide for pre-anesthesia fluid resuscitation.
methodsBefore general anesthesia induction, bedside ultrasonic measurement was performed to evaluate the maximum diameter (IJVmax-D) and minimum diameter (IJVmin-D) of the IJV and the maximum cross-sectional area (IJVmax-A) and minimum cross-sectional area (IJVmin-A), and then calculated the IJV diameter variability (IJVV-D) and IJV area variability (IJVV-A). A receiver operating characteristic (ROC) curve was used to determine the diagnostic value of IJVV-D and IJVV-A for predicting propofol induced hypotension (blood pressure decreased ≥ 20%) and calculate the cut-off value. The following prospective randomized controlled trial aimed to compare the incidence of anesthesia-induced hypotension between the IJVV-D or IJVV-A guided fluid administration (Group A) and the standard fluid administration group (Group B) in patients with the variability value > optimal cut-off value. The occurrence rate of hypotension during the propofol induction period was observed and compared between the two groups.
resultsA total of 60 patients were included in the final analysis. A significant strong correlation exists between IJVV-A and the degree of blood pressure decrease during deep inhalation (r = 0.858, p < 0.001). The AUC of IJVV-A was 0.900 (95% CI 0.821-0.979, p < 0.001) with a cut-off value of 23.42% (sensitivity: 81.5%, specificity: 84.8%). At the same time, a total of 87 patients with IJVV-A > 23.42% during deep inhalation were included in the data analysis. The incidence of hypotension in Group A was 26.8%, compared to 63.0% in Group B, revealing a statistically significant difference (P < 0.001).
conclusionsA significant relationship was observed between IJVV levels during deep inhalation and the blood pressure decline following propofol induction. Administering IJVV-A guided fluid infusion can significantly reduce propofol-induced hypotension by keeping the IJVV-A less than 23.42% during deep inspiration.
trial registrationSuccessfully registered on Clinicaltrials.gov on November 1, 2023 (NCT06112769) and on August 1, 2024 (NCT06641505).
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