Evidence map›Paper›PMID 40676495›Full record

ArticleHepatology international2025

Hepatitis C virus incidence trend and its risk factors among people who inject drugs in Hai Phong, Vietnam.

Hong Thi Tran, Huong Thi Duong, Khue Minh Pham, Binh Thanh Nguyen, Roselyne Vallo, Morgana D'Ottavi, Giang Thi Hoang, Vinh Hai Vu, Oanh Thi Hai Khuat, Thanh Tuyet Thi Nham and 10 more

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Article in Hepatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Hong Thi TranDepartment of Public Health, Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem Street, Ngo Quyen Dis, Hai Phong, Vietnam. tranthihong42@gmail.com.ORCID http://orcid.org/0000-0002-3881-6545
Huong Thi DuongDepartment of Public Health, Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem Street, Ngo Quyen Dis, Hai Phong, Vietnam.
Khue Minh PhamDepartment of Public Health, Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem Street, Ngo Quyen Dis, Hai Phong, Vietnam.
Binh Thanh NguyenDepartment of Public Health, Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem Street, Ngo Quyen Dis, Hai Phong, Vietnam.
Roselyne ValloPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Morgana D'OttaviPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Giang Thi HoangDepartment of Public Health, Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem Street, Ngo Quyen Dis, Hai Phong, Vietnam.
Vinh Hai VuInfectious and Tropical Diseases Department, Viet Tiep Hospital, 1 Nha Thuong Street, Le Chan Dis, Hai Phong, Hai Phong, Vietnam.
Oanh Thi Hai KhuatSupporting Community Development Initiatives, No.9 165/30 Alley, Thai Ha Street, Lang Ha Ward, Dong Da District, Hanoi, Vietnam.
Thanh Tuyet Thi NhamSupporting Community Development Initiatives, No.9 165/30 Alley, Thai Ha Street, Lang Ha Ward, Dong Da District, Hanoi, Vietnam.
Duc Quang NguyenDepartment of Public Health, Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem Street, Ngo Quyen Dis, Hai Phong, Vietnam.
Catherine QuilletPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Delphine RapoudPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Philippe Van de PerrePathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Jonathan FeelemyerSchool of Global Public Health, New York University, 708 Broadway, New York, NY, 10003, USA.
Laurent MichelParis Saclay University, Pierre Nicole Center, French Red Cross, CESP Inserm UMRS 1018, Paris, France.
Didier LaureillardPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Don Des JarlaisSchool of Global Public Health, New York University, 708 Broadway, New York, NY, 10003, USA.
Jean-Pierre MolesPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.
Nicolas NagotPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Francais du Sang, University of Antilles, 60 Rue de Navacelles, 34394, Montpellier, France.

Funding

DRIVE (DRug use and blood-borne Infections in ViEtnam): Combined prevention and care to end the HIV epidemic among people who inject drugs in Haiphong, Viet NamR01DA041978 · NIDA · NEW YORK UNIVERSITY · PI DES JARLAIS, DON C · 2016 to 2020
$4.9M
Agence Nationale de Recherches sur le Sida et les Hépatites Virales ANRS 12353NIDA NIH HHS R01 DA041978NIDA NIH HHS R01DA041978
6 · The paper itself

Abstract

backgroundHCV incidence among people who inject drugs (PWID) remains unacceptably high. Using the data from the DRIVE study, we aimed to describe HCV incidence trends and investigate its associated risk factors among PWID in Hai Phong, Vietnam.

methodsActive PWID were recruited through 3 annual respondent-driven sampling (RDS) surveys; part of them were included in the study cohorts. HCV seroincidence was calculated for PWID participating in multiple surveys (recaptures) or in cohorts. A nested case-control design was used for risk factor analysis. Controls were matched to HCV seroconversion cases on age, sex, cohort participation and HCV seroconversion visit. Risk factors were measured over the period preceding the HCV seroconversion visits.

resultsThere were 83 HCV seroconversions during 844 person-years in 540 included participants. The overall HCV incidence was 9.8/100 person-years (95% CI 7.9-12.2). HCV incidence decreased over follow-up time and was particularly high among PWID living with HIV (PLWH), i.e., 37.2/100 person-years (95% CI 26.4-52.3). HIV infection (OR = 10.0, 95% CI 6.8-16.2) and active heroin injection (OR: 3.2, 95% CI 2.3-4.8) were associated with a higher risk of HCV seroconversion for cohort participants. Among RDS recaptures, living with a sexual partner and currently using methadone had opposite effects on HCV incidence, OR = 2.9, 95% CI 2.2-4.3 and OR = 0.4, 95% CI 0.3-0.5, respectively.

conclusionHCV incidence among PWID in Hai Phong was still 5 times higher than the WHO target for elimination. Along with strengthened HCV prevention programs, affordable HCV treatment should be made available for PWID to reach the elimination goal.

Indexed as

Hepatitis CSubstance Abuse, IntravenousAdultCase-Control StudiesFemaleHepacivirusHIV InfectionsHumansIncidenceMaleMiddle AgedRisk FactorsVietnamActive heroin injectionDeterminantsHCV infectionHIVPLWHPWID

Identifiers

PMID40676495
PMCPMC12508010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.