ArticleJournal of clinical monitoring and computing2026
Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry.
Article in Journal of clinical monitoring and computing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Effect of ciprofol-assisted sedation on tourniquet-related responses in foot and ankle surgery: a randomized clinical trial.Therapeutic advances in drug safety · 2026Article
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- Critique on construction of a risk factor prediction model of postoperative complications of elderly patients with colorectal cancer using machine learning.Journal of robotic surgery · 2025Article
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21 authors.
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Abstract
purposePrevious cohort studies suggest that intraoperative hypotension is associated with acute kidney injury (AKI) in noncardiac surgical patients. We sought to ascertain that intraoperative hypotension is independently associated with AKI within the first 3 days after surgery in a contemporary cohort of noncardiac surgery patients in whom clinicians strove to avoid profound intraoperative hypotension.
methodsThis was a post hoc secondary analysis of the multicentre EU HYPROTECT registry, which includes patients undergoing major noncardiac surgery who underwent predictive blood pressure monitoring. The primary outcome of this secondary analysis was AKI within the first 3 days after surgery. To quantify the duration and severity of intraoperative hypotension we calculated the area under a mean arterial pressure (MAP) of 65 mmHg. We used logistic regression analysis to identify factors independently associated with AKI.
resultsWe analysed 697 patients. 62 of these 697 patients (9%) developed AKI within the first 3 days after surgery. In multivariable binary logistic regression analysis adjusted for confounding variables, the area under a MAP of 65 mmHg was independently associated with AKI within the first 3 days after surgery (OR 1.03 [95% CI 1.01-1.05] per 10 mmHg*min; P < 0.001).
conclusionOur secondary analysis of the EU HYPROTECT registry shows that, in a contemporary population of noncardiac surgery patients in whom clinicians strove to avoid profound intraoperative hypotension, intraoperative hypotension is independently associated with AKI within the first 3 days after surgery.
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