Evidence map›Paper›PMID 40676431›Full record

ReviewCurrent rheumatology reports2025

Cardiac Manifestations in Behçet's Syndrome.

Federica Bello, Giacomo Bagni, Emire Seyahi, Emanuele Chiara, Iacopo Olivotto, David Saadoun, Giacomo Emmi

Abstract readReview
In one paragraph

Review in Current rheumatology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Federica BelloDepartment of Experimental and Clinical Medicine, University of Florence, Italy and Internal Interdisciplinary Unit, Behçet Centre, Careggi University Hospital, Florence, Italy.
Giacomo BagniDepartment of Experimental and Clinical Medicine, University of Florence, Italy and Internal Interdisciplinary Unit, Behçet Centre, Careggi University Hospital, Florence, Italy.
Emire SeyahiDivision of Rheumatology, Department of Internal Medicine and Behçet's Disease Research Centre, Istanbul University-Cerrahpasa, School of Medicine, Istanbul, Turkey.
Emanuele ChiaraDepartment of Experimental and Clinical Medicine, University of Florence, Italy and Internal Interdisciplinary Unit, Behçet Centre, Careggi University Hospital, Florence, Italy.
Iacopo OlivottoDepartment of Experimental and Clinical Medicine, University of Florence, Italy and Internal Interdisciplinary Unit, Behçet Centre, Careggi University Hospital, Florence, Italy.
David SaadounDepartment of Internal Medicine and Clinical Immunology, Sorbonne University, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), 75013, Paris, France.
Giacomo EmmiDepartment of Medical, Surgical and Health Sciences, University of Trieste, Italy, and Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, Trieste, Italy. giacomo.emmi@units.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of the reviewBehçet's Syndrome (BS) is a multisystemic vasculitis that can affect the heart, leading to pericarditis, myocarditis, intracardiac thrombosis, endomyocardial fibrosis, valvular dysfunction, and coronary artery disease. This review summarizes the clinical presentation, diagnostic challenges, and therapeutic strategies for cardiac involvement in BS. RECENT

findingsAdvanced imaging techniques have revealed subclinical cardiac involvement in BS. Myocardial dysfunction and fibrosis contribute to heart failure and arrhythmias, while intracardiac thrombi often coexist with pulmonary artery involvement. Coronary artery vasculitis and aneurysms may mimic atherosclerotic disease, complicating diagnosis. Biologic therapies, including TNF-α inhibitors, show promise in refractory cases. Early diagnosis and immunosuppressive therapy are crucial. A multidisciplinary approach is essential to managing cardiac complications and optimizing patient outcomes. Future research should refine screening protocols and explore targeted immunotherapies for BS-related cardiovascular disease.

Indexed as

Behcet SyndromeHeart DiseasesHumansAneurysmsBehçetMyocarditisPericarditisThrombosisVasculitis

Identifiers

PMID40676431
PMCPMC12270964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.