Evidence map›Paper›PMID 40676412›Full record

ArticleJournal of gastrointestinal cancer2025

Imaging Characteristics and Clinical Outcomes in Gastric Cancer with Brain Metastasis: A Propensity Score-Matched Study.

Weihao Yang, Mengting Lu, Wangjiao He, Wenjun He, Xin Tan, Hengyi Zhang, Fengping Li, Liying Zhao, Ye Dong, Hao Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weihao Yang *Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Mengting Lu *Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Wangjiao He *NanFang PET Center, NanFang Hospital, Southern Medical University, GuangzhouGuangdong Province, 510515, China.
Wenjun HeDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Xin TanDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Hengyi ZhangDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Fengping LiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Liying ZhaoDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Ye DongNanFang PET Center, NanFang Hospital, Southern Medical University, GuangzhouGuangdong Province, 510515, China. dongye2010@126.com.
Hao LiuDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China. liuhaofbi@163.com.

Funding

Clinical Research Program of NanFang Hospital, Southern Medical University 2021CR003Key Areas Research and Development Programs of Guangdong Province 2023B1111050009Key Clinical Technique of Guangzhou 2023P-ZD01Natural Science Foundation of Guangdong Province 2023A1515010785
6 · The paper itself

Abstract

purposeThis study aimed to investigate the impact of brain metastasis (BM) on the clinical outcomes of gastric cancer (GC) and explored related imaging characteristics.

methodsGC patients of tumor stage IV treated at Nanfang Hospital from October 2004 to September 2022 were included. The comparisons of non-BM and BM group were used by propensity score matching (PSM). The Kaplan-Meier method was used to compare the overall survival (OS) and cancer-specific survival (CSS). Cox regression was used for multivariate analyses.

resultsA total of 1,051 patients were included. After PSM, non-BM group (n = 28) and BM group (n = 28) were more balanced in baseline variables. The OS (p < 0.05) and CSS (p < 0.05) of the BM group were inferior to those of the non-BM group. Multivariate Cox regression analysis suggests that brain metastasis is associated with poor OS (HR = 1.959, 95% CI: 1.031-3.721, p = 0.040) and CSS (HR = 1.988, 95% CI: 1.037-3.812, p = 0.038). Brain metastases predominantly occur in the frontal lobe (68.0%), followed by the parietal lobe (52.0%), and cerebellum (36.0%), these metastases frequently present with associated edema (65.1%) and necrosis (33.7%).

conclusionThe presence of brain metastasis is associated with poor OS and CSS. Brain metastases from GC commonly occur in the frontal lobe, parietal lobe, and cerebellum, with frequent imaging features of edema and necrosis.

Indexed as

Brain NeoplasmsStomach NeoplasmsAdultAgedBrainFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisPropensity ScoreRetrospective StudiesBrain metastasisEdemaGastric cancerNecrosisPrognosis

Identifiers

PMID40676412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.