ArticleOphthalmology and therapy2025
Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non-Lipid Hydroxypropyl Guar Formulations.
Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06784661 (Immediate Effects of Lipid-Based Artificial Tears), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immediate Effects of Lipid-Based Artificial Tears (Mineral Oil and Hydroxypropyl Guar) and Non-Lipid Artificial Tears (Hydroxypropyl Guar) on Corneal Aberrations in Healthy Individuals
Who cites it
2 citing papers in PubMed.
- Modulation of Total Corneal Astigmatism, Corneal Thickness, and Corneal Higher-Order Aberrations Following Tear-Enhancing Drop Instillation: A Retrospective Comparative Study.Ophthalmology and therapy · 2026Article
- Points to consider in designing and conducting astigmatism research in cataract surgery.Frontiers in ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo evaluate the immediate effects of two artificial tear formulations-mineral oil + hydroxypropyl guar (HP-Guar) and hyaluronic acid (HA) + HP-Guar-on ocular aberrations in healthy participants.
methodsA randomized, participant-masked clinical trial was conducted on 98 right eyes of 98 participants (mean age: 27.96 ± 10.00 years). Participants received a single instillation of either a lipid-based (mineral oil + HP-Guar) or non-lipid (HA + HP-Guar) artificial tear solution. Ocular aberrations were measured before and 10 min post-instillation using a wavefront aberrometer (i.Profilerplus
resultsThe mineral oil + HP-Guar formulation significantly reduced total RMS (p < 0.05) and low-order RMS (p < 0.05) at both 3-mm and 5-mm pupil diameters. Notable reductions were observed in defocus (Z
conclusionsLipid-based artificial tears provide superior optical quality by reducing total and low-order ocular aberrations, making them preferable for patients with tear film instability. In contrast, HA-based formulations primarily improve hydration with limited impact on optical performance. Artificial tear selection should consider both symptomatic relief and refractive stability, especially for individuals with high visual demands. CLINICAL
trial registrationThis study was registered as a randomized clinical trial on ClinicalTrials.gov under the identifier NCT06784661, titled the ILEACT study.
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