ArticleOphthalmology and therapy2025
Risk of Moderate to Severe Ocular Surface Disease Associated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy: A Multicenter Cohort Study.
Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Persistent Corneal Epithelial Defects Associated with Afatinib Therapy in a Patient with Non-Small Cell Lung Cancer: A Case Report.Korean journal of ophthalmology : KJO · 2025Article
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6 authors.
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Abstract
introductionModerate to severe ocular surface disease (OSD) can substantially impair quality of life in patients with lung cancer receiving epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy. Although multiple studies have reported cases of OSD associated with EGFR-TKI therapy, few have investigated major risk factors. In this study, we investigated the key risk factors for moderate to severe OSD in patients with lung cancer receiving EGFR-TKI therapy.
methodsThis multicenter retrospective (November 2004-December 2019) cohort study included 31,491 patients with lung cancer. Moderate to severe OSD was defined as severe conjunctivitis, dry eye disease necessitating at least step 2 treatment, keratitis, corneal ulcer, corneal perforation, or OSD necessitating surgery. Risk factors for moderate to severe OSD were investigated using univariate and multivariate Cox proportional hazards models.
resultsAmong 6677 eligible patients who received EGFR-TKI therapy, 220 (3.3%) developed moderate to severe OSD. Multivariate analysis revealed the following independent risk factors: female sex (hazard ratio [HR]: 1.43; 95% CI: 1.08-1.90), prior ocular surgery (HR: 4.15; 95% CI: 1.54-11.21), older age (HR: 1.16; 95% CI: 1.03-1.31), autoimmune disease (HR: 3.38; 95% CI: 1.38-8.25), peptic ulcer (HR: 1.90; 95% CI: 1.35-2.68), thyroid disease (HR: 2.34; 95% CI: 1.03-5.28), and systemic steroid use (HR: 1.50; 95% CI: 1.13-1.97). The following were specific risk factors for severe OSD: distant metastasis (HR: 3.29; 95% CI: 1.16-9.28), prior radiotherapy (HR: 2.29; 95% CI: 1.13-4.65), thyroid disease (HR: 3.78; 95% CI: 1.15-12.40), and high Charlson Comorbidity Index scores (HR: 1.11; 95% CI: 1.01-1.23).
conclusionPatients with the identified risk factors are at an elevated risk of moderate to severe OSD during EGFR-TKI therapy. Early recognition and timely intervention by ophthalmologists and oncologists in high-risk individuals may mitigate disease progression and improve quality of life.
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