Evidence map›Paper›PMID 40676355›Full record

ArticleObesity surgery2025

Treatment Pathways and Outcomes in Patients with BMI ≥ 50 kg/m

Sara Notz, Rainer Grotelueschen, Julia Pape, Bjoern-Ole Stueben, Louisa Stern, Julia Gerullies, Jonas Wagner, Anne Lautenbach, Jakob Robert Izbicki, Thilo Hackert and 5 more

Abstract read
In one paragraph

Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sara NotzDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rainer GrotelueschenDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julia PapeDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bjoern-Ole StuebenDepartment of General Surgery, Royal Perth Hospital, Perth, Australia.
Louisa SternDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julia GerulliesDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jonas WagnerDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anne LautenbachEndocrinology, Diabetes, Obesity, and Lipid Disorders, Outpatient Center of the University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Jakob Robert IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thilo HackertDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Philipp BuschDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anna DupreeDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dieter WeberDepartment of General Surgery, Royal Perth Hospital, Perth, Australia.
Oliver MannDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Gabriel PlitzkoDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. gabriel@plitzko.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery is the most effective treatment for patients with BMI ≥ 50 kg/m

methodsAll patients with BMI ≥ 50 kg/m

resultsOf 918 screened patients, 538 met inclusion criteria: Non-Surg (n = 203), Surg-First (n = 225), Step-Treat (n = 110). After 6 months, median % total weight loss (%TWL) and % excess weight loss (%EWL) were significantly higher in Surg-First (%TWL: 23.6% vs. 0%; %EWL: 42% vs. 0%; both P < .001) vs. Non-Surg. Surg-First showed higher diabetes remission (54.1% vs. 21.2%; P < .001) and fewer de novo diabetes cases. Compared to Surg-First, Step-Treat showed similar short-term weight loss but lower %TWL and %EWL at 12 and 24 months. Severe postoperative complications (Grade IIIb) were more common in Step-Treat (11.8% vs. 3.6%; P < .001), and SF-BARI QOL scores were higher in Surg-First.

conclusionIn patients with BMI ≥ 50 kg/m

Indexed as

Bariatric SurgeryConservative TreatmentObesity, MorbidAdultBody Mass IndexFemaleHumansMaleMiddle AgedQuality of LifeRetrospective StudiesTreatment OutcomeWeight LossComorbidity resolutionConservative treatmentMetabolic and bariatric surgeryObesity treatment pathwaysStepwise approachWeight loss outcomes

Identifiers

PMID40676355
PMCPMC12457228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.