Evidence map›Paper›PMID 40676338›Full record

ArticleWorld journal of urology2025

Novel risk predictor of spontaneous rupture and hemorrhage of renal cell carcinoma based on clinical and radiographic characteristics.

Bin Lin, Xiao-Dong Li, Meng-Xin Liu, Yu-Ting Xue, Xu-Yun Huang, Zhi-Bin Ke, Jia-Yin Chen, Fei Lin, Qing-Shui Zheng, Yong Wei and 3 more

Abstract read
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In one paragraph

Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Bin Lin *Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Xiao-Dong Li *Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Meng-Xin Liu *Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Yu-Ting Xue *Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Xu-Yun HuangDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Zhi-Bin KeDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Jia-Yin ChenDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Fei LinDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Qing-Shui ZhengDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Yong WeiDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Xue-Yi XueDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Shao-Hao ChenDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. shaohao.chen@fjmu.edu.cn.
Ning XuDepartment of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. drxun@fjmu.edu.cn.

Funding

Fujian Province Finance Project 2020B017Natural Science Foundation of Fujian Province 2022J01704
6 · The paper itself

Abstract

objectivesTo evaluate and validate clinical and imaging predictors of spontaneous rupture and hemorrhage (SRH) in renal cell carcinoma (RCC), and to develop an individualized risk prediction nomogram.

methodsA cohort of 914 RCC patients was analyzed. Clinical and imaging characteristics were compared between SRH and non-SRH groups, with baseline characteristics balanced using propensity score matching. Univariate analysis, logistic regression, and receiver operating characteristic (ROC) curve analysis were performed to identify SRH risk factors. A predictive nomogram was constructed and internally validated.

resultsAfter matching, baseline characteristics were comparable. Protective factors against SRH included posterior perirenal fat thickness (HR

conclusionsPerinephric fat stranding and the renal tumor vascular-to-renal artery diameter ratio are significant risk factors for SRH in RCC, while perirenal fat thickness and solid tumors are protective. Patients with fumarate hydratase deficiency are at increased SRH risk and require special clinical attention. The developed nomogram may assist in individualized risk assessment and clinical decision-making.

Indexed as

Carcinoma, Renal CellHemorrhageKidney NeoplasmsNomogramsAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsRupture, SpontaneousTomography, X-Ray ComputedComputed tomographyFumarate hydratasePerinephric fatRenal cell carcinomaSpontaneous rupture

Identifiers

PMID40676338

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