Evidence map›Paper›PMID 40676295›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Tibia length is an appropriate standard for evaluating hypertrophy in streptozotocin-induced diabetic complications.

Miao Qin, Feng Shao, Teresa Fernandez, Yixin Wang, Thomas Wieland, Christiane Vettel, Yuxi Feng

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miao Qin *Experimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
Feng Shao *Experimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
Teresa FernandezExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
Yixin WangExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
Thomas WielandExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
Christiane VettelExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
Yuxi FengExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany. Yuxi.feng@medma.uni-heidelberg.de.

Funding

Deutsche Forschungsgemeinschaft 511337830Deutsche Forschungsgemeinschaft 512541541
6 · The paper itself

Abstract

The pathogenesis of diabetic complications has been extensively studied in streptozotocin (STZ)-induced diabetic mice. Body weight (BW) is still used to standardize organ hypertrophy, but it may be unreliable due to significant weight loss in this model. This study aimed to assess the reliability of using tibia length (TL) as a common standard for organ hypertrophy in emaciated diabetic mice. Diabetes was induced by STZ in wild type mice with C57BL6/N (6N) and BL6/J (6J) background. TL and the weights of the heart (HW), kidneys (KW), and bladder (BLW) were estimated at 1-, 3-, and 6-month post-diabetes induction. The 6N mice were more sensitive to STZ than the 6J mice. In 1-month diabetic mice, the HW, HW/TL, and HW/TL

Indexed as

Diabetes ComplicationsDiabetes Mellitus, ExperimentalTibiaAnimalsBody WeightHypertrophyKidneyMaleMiceMice, Inbred C57BLOrgan SizeReproducibility of ResultsSpecies SpecificityStreptozocinUrinary BladderStreptozocinBody weightC57 BL/6 substrainDiabetic complicationsHypertrophyStandardTibias

Identifiers

PMID40676295
PMCPMC12894438

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.