Evidence map›Paper›PMID 40676285›Full record

ArticleDiscover oncology2025

High expression of DGKA indicates poor overall survival of nasopharyngeal carcinoma.

Hao Chen, Runduan Lin, Qi Yuan, Xiaohang Gao, Lin Zhang, Rong Zhang

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Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hao Chen *State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.
Runduan Lin *State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.
Qi YuanState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.
Xiaohang GaoState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.
Lin ZhangState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China. zhanglin@sysucc.org.cn.
Rong ZhangState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China. zhangrong@sysucc.org.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81773244the Guangdong Esophageal Cancer Institute Science and Technology Program M202221the Natural Science Foundation of Guangdong Province 2022A1515012447
6 · The paper itself

Abstract

backgroundNasopharyngeal carcinoma (NPC) is a malignant tumor with strong tendency of metastasis and recurrence. Therefore, prognostic indicators for NPC are urgently needed. DGKA is overexpressed in many cancers. However, the role of DGKA in NPC remains unclear. The aim of this study is to investigate the expression patterns and prognostic value of DGKA in NPC.

methodsThe mRNA expression of DGKA was analyzed from the dataset of The Cancer Genome Atlas (TCGA). Immunohistochemistry was performed to detect the expression of DGKA in 124 paraffin-embedded samples. Survival analysis was conducted according to the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to identify the independent prognostic factors.

resultsWe found the mRNA expression of DGKA was significantly higher in tumor tissues than in adjacent tissues in TCGA datasets. Besides, the comparison of the different clinicopathological features of NPC between high and low DGKA expression groups revealed that high DGKA expression was related to the survival status (p = 0.008). Statistical analysis indicates that high expression of DGKA is associated with poor prognosis in NPC. A monogram model was successfully established and demonstrated favorable predictive performance. Bioinformatics analysis showed that DGKA was associated with the activation of oncogenic signaling pathways and the reduction of anti-tumor CD8 + T cell infiltration.

conclusionHigh expression of DGKA is associated with poor overall survival of NPC patients. DGKA is expected to be a potential biomarker and therapeutic target for NPC.

Indexed as

Bioinformatic analysisClinical prognosisDGKANasopharyngeal carcinoma

Identifiers

PMID40676285
PMCPMC12271027

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