ArticlePediatric research2026
Preterm functional outcomes are reflected in early postnatal proteome changes.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Time-resolved urinary proteomics reveals heme-associated oxidative stress responses in neonatal hypoxic-ischaemic encephalopathy.Molecular and cellular pediatrics · 2026Article
- Uncovering Urinary Proteome Differences in Very Preterm Infants with and without Preterm Brain Injury.Journal of proteome research · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundAdvances in omics technologies have enabled precise analysis of protein abundance. This study applies such methods to investigate urinary proteomic quantitative changes associated with prematurity.
methodsUrine samples were collected from very-low-gestational-age (VLGA) infants (n = 29) without premature brain damage, as assessed using the Kidokoro scale and magnetic resonance imaging at term-equivalent age, and from full-term infants (n = 19) on the 1
resultsWe identified 61 proteins that were significantly differentially abundant in urine throughout the study. The regulated urinary proteins were enriched in functional domains related to the immune system, hemostasis, and complement and coagulation cascades, indicating underdevelopment in VLGA infants. Conversely, the augmented pathways included extracellular matrix organization, cholesterol metabolism and PPAR signaling.
conclusionsThe urinary proteome of VLGA infants differed significantly from that of term neonates, revealing protein profiles linked to immune system immaturity and hemostasis, altered metabolism and perturbed extracellular matrix metabolism. This study underscores how prematurity affects the urinary proteome, offering insights into the molecular pathways influenced by premature birth. IMPACT: The urinary proteome of premature newborns differs from the urinary proteome of full-term newborns; analysis of urine proteins indicates the functional consequences of prematurity. In our study, we tested urine on the 1
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