ArticleHeredity2026
Multiple forms of balancing selection maintain inversion polymorphism.
Article in Heredity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Genomic signatures of adaptation across a landscape of crickets following the introduction of a parasitoid fly.Science advances · 2026Article
- Variable jackpot individuals provide most alleles for repeated, rapid adaptation to freshwater by anadromous Threespine Stickleback.bioRxiv : the preprint server for biology · 2026Article
- Shifting Balancing Selection Underlies an Inversion Cline in Eurasian Blackcap.Ecology and evolution · 2026Article
- The geometry of dominance shows broad potential for stable polymorphism under antagonistic pleiotropy.bioRxiv : the preprint server for biology · 2026Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Despite many examples of balanced inversion polymorphisms, little is known about how they affect fitness-related traits. This knowledge gap hampers our understanding of how they are selectively maintained as protected polymorphisms. Here, we study the effects of a cosmopolitan balanced inversion polymorphism in D. melanogaster, In(3R)Payne, on fitness components, including traits related to development, growth, reproduction, stress resistance, and adult survival. We find that the non-inverted standard (STD) chromosomal arrangement and the inverted (INV) arrangement behave like Mendelian alleles of a supergene, which affect a suite of complex fitness-related phenotypes. While the STD arrangement tends to have positive, mostly dominant effects on size-related traits, fecundity, fertility, stress resistance, and lifespan, the INV arrangement exhibits mostly recessive effects that are indicative of fitness costs. Yet, in favor of the balanced polymorphism, we observe overdominance for egg hatchability, egg-to-adult survival, pupal survival at 18 °C, developmental time, and male desiccation resistance. The most parsimonious explanation for these heterotic effects is that they are due to some form of multi-locus heterokaryotype advantage. We also find several instances of trait-, sex-, and temperature-dependent changes in the degree of dominance, suggesting a possible role of antagonistic selection with context-specific dominance reversals in maintaining the polymorphism. Moreover, genotype-by-environment interactions and parental effects appear to contribute as well. Together, our results suggest that multiple phenotypic modes of balancing selection are involved in maintaining the inversion polymorphism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.