Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework.

Zongsu Han, Tiankai Sun, Peng Cheng, Wei Shi

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Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zongsu HanFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin, China.

Tiankai SunFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin, China.

Peng ChengFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin, China.ORCID http://orcid.org/0000-0003-0396-1846

Wei ShiFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin, China. shiwei@nankai.edu.cn.ORCID http://orcid.org/0000-0001-6130-1227

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chirality plays a pivotal role in the properties of biologically active molecules, with enantiomers exhibiting divergent pharmacological and toxicological profiles. Enantioselective recognition is thus crucial in drug development, asymmetric synthesis, and environmental monitoring. Luminescence sensing has emerged as a powerful strategy for enantioselective recognition due to its fast response and visual readout capabilities. Covalent-organic frameworks (COFs) offer a promising platform for such applications by combining structural robustness, modular functionality, and inherent porosity. However, achieving both high enantioselectivity and quantitative sensing within a single system remains highly challenging. Herein, we present a cation-induced strategy for enantioselective sensing using a terbium-loaded chiral COF, Tb@CD-COF. Through a facile cation exchange of piperazine cations of CD-COF with Tb

Identifiers

PMID40676229

DOI10.1038/s42004-025-01605-z

PMCPMC12271515

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.