ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Clinical outcomes after implementation of a physiologic pre-operative management strategy in neonates with congenital diaphragmatic hernia.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Hemodynamic Phenotypes in Congenital Diaphragmatic Hernia: Unresolved Questions and Future Directions.Children (Basel, Switzerland) · 2026Article
- NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Born under pressure: cardiac adaptation in congenital diaphragmatic hernia.Pediatric research · 2026Article
- Congenital diaphragmatic hernia: are improvements in ECMO & survival sustainable over time?Journal of perinatology : official journal of the California Perinatal Association · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate neonatal outcomes in congenital diaphragmatic hernia (CDH) after implementation of new preoperative management guidelines based on physiologic fetal-to-neonatal transition. STUDY
designA retrospective single-center study of neonates with CDH was performed. Data were collected from 48 infants treated prior to new guideline implementation (Epoch 1) and 13 patients treated after implementation (Epoch 2). We hypothesized that rates of extracorporeal life support (ECLS) and inhaled nitric oxide (iNO) utilization would decrease after guideline implementation.
resultsNeonates from Epoch 2 had a lower need for ECLS (p = 0.009) and iNO (p < 0.001) compared to Epoch 1. Compared to Epoch 1, neonates in Epoch 2 had decreased invasive mechanical ventilation duration (p = 0.001).
conclusionImplementation of physiologically driven management guidelines led to reduced rates of ECLS cannulation, ventilator days, and iNO utilization. This study demonstrates the impact of pre-operative physiologic management in improving short-term outcomes of CDH patients.
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Registered trials
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