ArticlePediatric radiology2025
Interobserver variability in assessing preoperative imaging biomarkers for cerebellar mutism syndrome: a multiobserver pilot study.
Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association between perioperative factors and the occurrence of postoperative cerebellar mutism syndrome in children.Frontiers in neurology · 2026Article
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9 authors.
Funding
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Abstract
backgroundCerebellar mutism syndrome is a well-known complication of paediatric posterior fossa tumour surgery. In recent years, several imaging biomarkers have been suggested to predict cerebellar mutism syndrome based on its probable pathoanatomical causes.
objectiveThis study investigates the reliability of preoperative imaging biomarkers for cerebellar mutism syndrome in paediatric posterior fossa tumours. Specifically, it examines the interobserver agreement on the size, invasion, and compression of selected regions of interest with structured magnetic resonance imaging (MRI) reporting. MATERIALS AND
methodsPreoperative brain MRI scans from ten paediatric patients with posterior fossa tumours, conducted at a single institution, were analysed. The scans were evaluated by three neuroradiologists from three different institutions across two countries using a structured reporting format. The interobserver agreement was assessed using intraclass correlation coefficient and Fleiss' kappa. All estimates were reported with a 95% confidence interval.
resultsThe study found good to excellent agreement in measuring tumour size, tumour volume, and the Evans index. Substantial agreement was found in tumour pathology and location. However, the interobserver agreement was unreliable for invasion and compression of the included anatomical structures.
conclusionFindings from this study challenge the reliability of preoperative imaging biomarkers for cerebellar mutism syndrome, emphasising the need for further investigation into consistent and reproducible biomarkers relevant to this syndrome.
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