ArticleScientific reports2025
Clinical outcomes of continuous local antibiotic perfusion in combination with debridement antibiotics and implant retention for periprosthetic hip joint infection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Local antibiotic treatment for periprosthetic joint infection: current approaches and the emerging role of continuous local antibiotic perfusion.International orthopaedics · 2026Review
- Antibiotic-Releasing Porous Shell Cements.Antibiotics (Basel, Switzerland) · 2026Article
- Continuous Local Antibiotic Perfusion for Refractory Musculoskeletal Infections: Functional and Patient-reported Outcomes in a 13-Case Series.Journal of orthopaedic case reports · 2026Article
- The Mursa Protocol: A Novel Multimodal Antiseptic-Based DAIR Strategy for Early Hip Periprosthetic Joint Infection.Antibiotics (Basel, Switzerland) · 2026Article
- Antibiotic-Loaded PLA Composites for Local Prevention of Implant-Associated Infections: Comparative Evaluation Against Reference Strains and Clinical Isolates.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Novel Therapies for Prosthetic Joint Infections Caused by Methicillin-ResistantPathogens (Basel, Switzerland) · 2025Review
- Current Concepts of Local Antibiotic Delivery in Bone and Joint Infections-A Narrative Review of Techniques and Clinical Experiences.Microorganisms · 2025Review
- Continuous Local Antibiotic Perfusion: A Novel Technique for the Treatment of Orthopaedic Infections: Narrative Review.JB & JS open accessReview
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periprosthetic joint infection (PJI) is a complication of peri-implant biofilm-based treatments and confers resistance to antimicrobial therapy. Integrating continuous local antibiotic perfusion (CLAP) with conventional surgery for PJI facilitates the local delivery of low-flow, high-concentration antimicrobials. This study aimed to evaluate the efficacy and safety of CLAP for treating PJI. This study included patients diagnosed with hip PJI who underwent debridement, antibiotics, and implant retention (DAIR) augmented by CLAP. Gentamicin was administered at a high concentration (1.2 mg/mL) and low flow rate (2.0 mL/h for 24 h). We evaluated implant survival and complication rates associated with adding CLAP to conventional DAIR surgery. Of the 22 patients, including 11 with chronic infection, DAIR surgery supplemented with CLAP resulted in implant survival in 20 patients (90.9%). In contrast, among 10 patients treated with DAIR without CLAP (non-CLAP group), implant survival was 70%. The mean follow-up period was 42.6 ± 31.5 (range, 12-161) months in the CLAP group and 56.8 ± 28.8 (range, 28-114) months in the non-CLAP group. During CLAP treatment, renal function worsened in two patients; however, it improved rapidly after CLAP completion and device removal. No major complications were observed. CLAP demonstrated promising results in treating acute and chronic PJI. However, monitoring and regulating blood antimicrobial levels is crucial to avoiding renal dysfunction. CLAP is a treatment option for PJI that can destroy bacterial biofilms.
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