Evidence map›Paper›PMID 40676133›Full record

ArticleScientific reports2025

Development and validation of a Japanese version of the multimorbidity treatment burden questionnaire.

Takuya Aoki, Tadao Okada, Shoichi Masumoto, Ryota Takahashi, Yusuke Kanakubo, Makoto Oura, Masato Matsushima, Polly Duncan

Abstract readValidation Study
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takuya AokiDivision of Clinical Epidemiology, Research Center for Medical Sciences, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato- ku, Tokyo, 105-8461, Japan. taoki@jikei.ac.jp.
Tadao OkadaTesshoukai Kameda Family Clinic Tateyama, Chiba, Japan.
Shoichi MasumotoDepartment of Family Medicine, General Practice and Community Health, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Ryota TakahashiTesshoukai Kameda Family Clinic Tateyama, Chiba, Japan.
Yusuke KanakuboDivision of Clinical Epidemiology, Research Center for Medical Sciences, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato- ku, Tokyo, 105-8461, Japan.
Makoto OuraDepartment of General Medicine, Nanto Municipal Hospital, Toyama, Japan.
Masato MatsushimaDivision of Clinical Epidemiology, Research Center for Medical Sciences, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato- ku, Tokyo, 105-8461, Japan.
Polly DuncanCentre for Academic Primary, Care, Bristol Medical School, University of Bristol, Bristol, UK.

Funding

Japan Society for the Promotion of Science JP23K16269
6 · The paper itself

Abstract

This study aimed to develop a Japanese version of the Multimorbidity Treatment Burden Questionnaire (J-MTBQ) and examine its validity and reliability. The MTBQ was translated into Japanese using forward and backward translation and cognitive interviews assessed content validity in a Japanese context. We conducted a nationwide postal survey using a representative panel of the Japanese adult population. Eligible participants in this study were patients with multimorbidity (≥ 2 long-term conditions). Structural validity, convergent validity, known-groups validity, and internal consistency reliability were assessed. Cognitive interviews found good acceptability and content validity. The survey was completed by 383 patients. Confirmatory factor analysis supported the scale's structural validity and a one-factor solution. In hypothesis testing, the J-MTBQ score had a negative association with health-related quality of life and self-rated health; and a positive association with the number of long-term conditions and prescribed medications. Cronbach's alpha indicated a high level of internal consistency reliability. We have developed a J-MTBQ and examined its validity and reliability. This scale can be used to identify patients experiencing high treatment burden, to improve the quality of care for patients with multimorbidity, and to assess the impact of interventions for multimorbidity in Japanese-speaking adults.

Indexed as

MultimorbiditySurveys and QuestionnairesAdultAgedAged, 80 and overCost of IllnessEast Asian PeopleFemaleHumansJapanMaleMiddle AgedPsychometricsQuality of LifeReproducibility of ResultsMultimorbidityPolypharmacyPrimary health careTreatment burden

Identifiers

PMID40676133
PMCPMC12271562

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.