Evidence map›Paper›PMID 40676130›Full record

ArticleNPJ digital medicine2025

Evaluation of an integrated digital and mobile intervention to improve outcomes for patients with moderate to severe COPD.

Laurel O'Connor, Biqi Wang, Zehao Ye, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Leah Dunkel, Brandon Savage, Thomas Scornavacca and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Implementing acute exacerbations of COPD care bundles: evidence, effectiveness and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Laurel O'Connor *Program in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. laurel.oconnor@umassmed.edu.
Biqi Wang *Program in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Zehao YeDivision of Health System Science, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Stephanie BeharProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Seanan TarrantProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Pamela StamegnaProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Caitlin PretzProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Leah DunkelProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Brandon SavageCareEvolution, Limited Liability Company, Ann Arbor, MI, USA.
Thomas ScornavaccaDepartment of Community Medicine and Family Health, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jeanne ShirshacOffice of Clinical Integration, University of Massachusetts Memorial Healthcare, Worcester, MA, USA.
Tracey WilkieOffice of Clinical Integration, University of Massachusetts Memorial Healthcare, Worcester, MA, USA.
Shaun ToomeyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Marie MullenDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kimberly FisherDivision of Health System Science, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Emil TigasDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Steven WongDivision of Health Informatics and Implementation Science, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
David D McManusProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Eric AlperProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Fernando MartinezDivision of Health System Science, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Allan WalkeyDivision of Health System Science, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Peter K LindenauerDepartment of Healthcare Delivery and Population Sciences and Department of Medicine, University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA.
Eric DicksonProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
John P BroachProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Vik KheterpalCareEvolution, Limited Liability Company, Ann Arbor, MI, USA.
Apurv SoniProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Funding

University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0M
University of Pittsburgh Clinical and Translational Science InstituteTL1TR000145 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$872k
NCATS NIH HHS KL2TR00145NCATS NIH HHS TL1 TR000145NCATS NIH HHS UL1 TR001453NCATS NIH HHS UL1TR001453
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) leads to high rates of emergency department (ED) visits and hospitalizations. This study evaluated a community-based digital health intervention's association with acute care utilization among patients with moderate to severe COPD. In a decentralized, nonrandomized trial, participants received biometric monitoring, symptom tracking, on-demand paramedic services, and digital pulmonary rehabilitation for 6 months. Outcomes were compared to a synthetic control group using weighted optimal matching and multivariable-adjusted regression. The primary outcome was hospitalization; secondary outcomes included readmission rates, ED visits, length of stay, and mortality. Eighty-eight intervention participants (mean age 67 (SD 10)) were compared to a weighted control group of 14,492 (mean age 69 (SD 11)). Intervention participants had lower odds of hospitalization (OR 0.67, 95% CI: 0.46-0.98) and 30-day readmission (OR 0.38, 95% CI: 0.17-0.84). This digital and mobile intervention was associated with reduced acute care use and supports further evaluation of hybrid care models for COPD.

Identifiers

PMID40676130
PMCPMC12271324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.