Evidence map›Paper›PMID 40676118›Full record

ArticleScientific reports2025

Direct synthesis of mycophenolic acid aryl esters with antioxidant and antiproliferative properties.

Juliusz Walczak, Dorota Iwaszkiewicz-Grześ, Magdalena Śliwka-Kaszyńska, Agnieszka Kurdyn, Ewa Augustin, Agnieszka Viapiana, Alina Plenis, Grzegorz Cholewiński

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juliusz WalczakDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, Gdańsk, 80-233, Poland.
Dorota Iwaszkiewicz-GrześDepartment of Medical Immunology, Faculty of Medicine, Medical University of Gdansk, ul. Dębinki 7, Gdańsk, 80-210, Poland.
Magdalena Śliwka-KaszyńskaDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, Gdańsk, 80-233, Poland.
Agnieszka KurdynDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, Gdańsk, 80-233, Poland.
Ewa AugustinDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, Gdańsk, 80-233, Poland.
Agnieszka ViapianaDepartment of Analytical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, Gdańsk, 80-416, Poland.
Alina PlenisDepartment of Analytical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, Gdańsk, 80-416, Poland.
Grzegorz CholewińskiDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, Gdańsk, 80-233, Poland. grzchole@pg.edu.pl.

Funding

Gdańsk University of Technology DS035136Medical University of Gdańsk 02-10022/272
6 · The paper itself

Abstract

Naturally occurring phenols were incorporated into the mycophenolic acid (MPA) core to form sixteen new MPA derivatives. Ester conjugates of MPA with isoeugenol, methyl o-coumarate, and raspberry ketone exhibited the highest antioxidant activity in the DPPH test. These derivatives were then tested against the human pancreatic cancer AsPC-1 cells, showing cytotoxicity similar to that of the referential parent compounds MPA and mycophenolate mofetil (MMF). Subsequently, most of the obtained MPA esters proved activity against the T-Jurkat cells and peripheral blood mononuclear cells (PBMCs), serving as an immunosuppressive model, and worked as inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. The most promising immunosuppressive conjugates were the esters of MPA with sesamol and raspberry ketone structural motifs, which held the highest selectivity index (SI) for PBMCs, thus serving as a good starting point for new drug development.

Indexed as

Antineoplastic AgentsAntioxidantsEstersMycophenolic AcidCell Line, TumorCell ProliferationHumansIMP DehydrogenaseJurkat CellsLeukocytes, MononuclearAntineoplastic AgentsAntioxidantsEstersIMP DehydrogenaseMycophenolic AcidAntioxidantsEsterificationIMPDH inhibitionMycophenolic acidNatural phenols

Identifiers

PMID40676118
PMCPMC12271471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.