Evidence map›Paper›PMID 40676043›Full record

SynthesisScientific reports2025

Non-invasive brain stimulation contributing to postural control with and without stroke: a systematic review and meta-analysis.

Sangha Cha, Jayoung Choi, Changwon Moon, Kanghee Cho

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sangha ChaDepartment of Rehabilitation Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Jayoung ChoiDepartment of Rehabilitation Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Changwon MoonDepartment of Rehabilitation Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Kanghee ChoDepartment of Rehabilitation Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea. khcho@cnu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive brain stimulation techniques demonstrate promising potential for enhancing neural plasticity and motor recovery, yet their comparative effectiveness for improving postural control across neurologically impaired and intact populations requires systematic investigation. This systematic review and meta-analysis evaluated the therapeutic efficacy of brain stimulation modalities on postural control, comparing outcomes between stroke survivors and neurologically intact adults through controlled trials. Systematic searches were conducted across major databases (CINAHL, Embase, MEDLINE, Web of Science) for randomized controlled trials and crossover studies published from 2014 to 2024. Study quality was assessed using the Risk of Bias 2 tool, with treatment effects analyzed through standardized mean differences in a random-effects model. Analysis of 15 studies revealed significant overall effects of brain stimulation (SMD = 0.79, 95% CI 0.47-1.11), with notably stronger responses in stroke participants (SMD = 0.95) versus neurologically intact individuals (SMD = 0.39). Transcranial direct current stimulation showed particular efficacy in stroke rehabilitation (SMD = 1.79), while intermittent theta burst stimulation demonstrated moderate effects (SMD = 0.68). Primary motor cortex stimulation yielded optimal outcomes (SMD = 1.21), followed by cerebellar (SMD = 0.75) and dorsolateral prefrontal cortex interventions (SMD = 0.35). These findings reveal differential response patterns between populations and stimulation parameters, suggesting enhanced neuroplastic potential in stroke survivors. This evidence supports the development of targeted neuromodulatory approaches for rehabilitation and performance enhancement.

Indexed as

BrainPostural BalanceStrokeStroke RehabilitationTranscranial Direct Current StimulationTranscranial Magnetic StimulationHumansNeuronal PlasticityBrain stimulationPostural balanceStrokeTranscranial direct current stimulationTranscranial magnetic stimulation

Identifiers

PMID40676043
PMCPMC12271516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.