ArticleNature communications2025
Atroposelective construction of axially chiral alkenylindole-fused nine-membered rings via catalytic asymmetric formal (4 + 5) cycloaddition.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Enantioselective synthesis of ring-constrained biaryls via a twist-expand-seal strategy.Nature communications · 2026Article
- Synergistic decatungstate and Brønsted acid catalysis enables direct C-H indolation of alkanes and aldehydes.Chemical science · 2026Article
- Atroposelective construction of indole-fused diazocinesChemical science · 2026Article
- Catalytic asymmetric formal nucleophilic C2-substitution of indoles via C2-umpolung toward 2,3'-bisindole atropisomers.Nature communications · 2026Article
- Access to Fluorene-Fused Isoquinolones Containing an Axially Chiral Element via Cascade Bi-Annulation Reaction of Indene-Dienes.Precision chemistry · 2026Article
- Stereogenic S‑Induced Generation of Axially Chiral Cyclic Vinyl Sulfinamides and Serendipitous Diastereomeric Enrichment.JACS Au · 2026Article
- Recent developments in the organocatalytic asymmetric cycloaddition/annulation reactions involving indolylmethanols.RSC advances · 2026Review
- Bulky alkali metal cations enabled highly efficient iridium-catalyzed asymmetric hydrogenation for C-N axial chiralityChemical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Catalytic atroposelective construction of axially chiral aryl-fused medium-sized rings, particularly nine-membered rings, is of great importance but with enormous challenges. To overcome these challenges, in this work, the catalytic atroposelective construction of axially chiral arylalkene-fused nine-membered rings has been established, which makes use of organocatalytic asymmetric formal (4 + 5) cycloaddition of 3-alkynyl-2-indolylmethanols with 2-indolylethanols. By this strategy, various axially chiral alkenylindole-fused nine-membered rings were constructed in high enantioselectivities with moderate to good yields (up to 74% yield, 98% ee). Theoretical calculations provide an in-depth understanding on the reaction pathway and activation mode of the organocatalytic asymmetric formal (4 + 5) cycloaddition, and application explorations demonstrate the great potential of these axially chiral arylalkene-fused nine-membered rings in asymmetric catalysis and medicinal chemistry. Besides, this strategy could be extended to organocatalytic formal (4 + 4) cycloaddition of 3-alkynyl-2-indolylmethanols with 2-indolylmethanols. This work has not only realized the organocatalytic asymmetric formal (4 + 5) cycloaddition, but also provided an efficient strategy for the synthesis of axially chiral aryl-fused nine-membered rings, which will greatly advance the chemistry of cycloadditions and atropisomers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.