Evidence map›Paper›PMID 40676026›Full record

ArticleScientific reports2025

Multi modal optical coherence tomography flowmetry of organ on chip devices.

Devrim Tugberk, Konstantine Cheishvili, Peter Speets, William Quirós-Solano, Anish Ballal, Nikolas Gaio, Jeroen Kalkman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Devrim Tugberk *Department of Imaging Physics, Delft University of Technology, Lorentzweg 1, Delft, The Netherlands.
Konstantine Cheishvili *Department of Imaging Physics, Delft University of Technology, Lorentzweg 1, Delft, The Netherlands.
Peter SpeetsDepartment of Imaging Physics, Delft University of Technology, Lorentzweg 1, Delft, The Netherlands.
William Quirós-SolanoBIOND Solutions B.V., Molengraaffsingel 10, Delft, The Netherlands.
Anish BallalBIOND Solutions B.V., Molengraaffsingel 10, Delft, The Netherlands.
Nikolas GaioBIOND Solutions B.V., Molengraaffsingel 10, Delft, The Netherlands.
Jeroen KalkmanDepartment of Imaging Physics, Delft University of Technology, Lorentzweg 1, Delft, The Netherlands. j.kalkman@tudelft.nl.

Funding

NWO domain Applied and Engineering Sciences 17988NWO domain Applied and Engineering Sciences P17-24
6 · The paper itself

Abstract

Organ-on-chip (OoC) systems are microfluidic devices for maintaining live tissue under physiologically relevant (flow) conditions. Imaging of structure and flow is important for the characterization of OoC device design and visualizing tissue/fluid interaction. Here, we present 3D tissue and flow imaging in an OoC device with multi-modal optical coherence tomography (OCT) using a combination of OCT structural imaging and flow imaging with Doppler OCT, number fluctuation dynamic light scattering OCT, and particle image velocimetry OCT. We demonstrate the feasibility of combined imaging of OoC tissue culture morphology and high flow velocities. We also measure low velocities in the OoC tissue well showing good agreement with computational fluid dynamics simulations. Our results open up the way for studying the effect of flow on living tissue in OoC devices.

Indexed as

Lab-On-A-Chip DevicesRheologyTomography, Optical CoherenceAnimalsImaging, Three-Dimensional

Identifiers

PMID40676026
PMCPMC12271446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.