A retrospective cohort study on perinatal outcomes of monochorionic and dichorionic twin pregnancies complicated by intrahepatic cholestasis of pregnancy.

Shuang Luo, Jiayi Mao, Li Wen, Ya Chen, Jiayin Li, Wenti You, Yajun Yang

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1 citing paper in PubMed.

Early postnatal risk stratification for severe adverse outcomes in twin neonates admitted to the neonatal intensive care unit: development and temporal validation of an interpretable machine learning model.Translational pediatrics · 2026
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7 authors.

Shuang Luo *Department of Anesthesiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.

Jiayi Mao *Department of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China.

Li WenDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China.

Ya ChenDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China.

Jiayin LiDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China.

Wenti YouDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China.

Yajun YangDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, China. 394546132@qq.com.

Funding

Sichuan Province Science and Technology Support Program 2023YFQ0005

6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder and may cause adverse perinatal outcomes. However, few studies reported differences in perinatal outcomes of monochorionic(MC) and dichorionic(DC) twin pregnancies complicated by ICP. These perinatal outcomes were assessed with a retrospective cohort study. This was a retrospective observational study of MC and DC twin pregnancies complicated by ICP. Cases were divided into the MC group and DC group, perinatal outcomes were compared, and predictors of adverse perinatal outcomes were evaluated. In total, 363 twin pregnancies complicated by ICP (93 MC, 270 DC) were included. Compared with DC twin pregnancies, MC pregnancies were characterized by younger age, lower pre-pregnancy weight and lower pre-pregnancy body mass index (p < 0.05). Delivery of MC twins was more likely to occur between 34 and 37 weeks, averaging 34.87 ± 2.42 gestational weeks. Additionally, both twins A and B in the MC group weighed less than those in the DC group (p < 0.001). After adjustment for confounders, GA at diagnosis < 32 weeks (aOR = 1.096, 95% CI 1.031-2.393, p = 0.000) was an independent risk factor in MC twin pregnancies, while GA at diagnosis < 32 weeks(aOR = 13.626, 95% CI 1.783-14.177, p = 0.012) and AST > 200 U/L (aOR = 3.178, 95% CI 1.252-8.068, p = 0.015) were independent risk factors for adverse perinatal outcomes in DC twin pregnancies. Our results indicated that some liver function biochemical indicators could predict poor foetal outcomes in twin pregnancies complicated by ICP. Greater emphasis should be placedon monitoring of predelivery liver functional biochemical indexes in pregnant women according to chorionicity complicated by ICP, to facilitate personalized antenatal management and improve neonatal outcomes.

Indexed as

Cholestasis, IntrahepaticPregnancy ComplicationsPregnancy OutcomePregnancy, TwinAdultFemaleGestational AgeHumansInfant, NewbornPregnancyRetrospective StudiesRisk FactorsTwins, DizygoticTwins, MonozygoticDichorionicIntrahepatic cholestasis of pregnancy (ICP)MonochorionicPerinatal outcomesRetrospective studyTwin pregnancy

Identifiers

PMID40676023

DOI10.1038/s41598-025-09792-4

PMCPMC12271304

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