Evidence map›Paper›PMID 40676001›Full record

ArticleNPJ Parkinson's disease2025

Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus.

Brendan Santyr, Alexandre Boutet, Mohamad Abbass, Artur Vetkas, Jürgen Germann, Afis Ajala, Jianwei Qiu, Gavin J B Elias, Can Sarica, Andrew Z Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Impact of subthalamic nucleus deep brain stimulation on voice and speech in Parkinson's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Brendan Santyr *Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Alexandre Boutet *Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Mohamad AbbassDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Artur VetkasDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Jürgen GermannDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Afis AjalaGE Research, Niskayuna, NY, USA.
Jianwei QiuGE Research, Niskayuna, NY, USA.
Gavin J B EliasDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Can SaricaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Andrew Z YangDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Ibrahim AlhashyanEdmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital-UHN. Division of Neurology, University of Toronto, Toronto, ON, Canada.
Suneil K KaliaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Alfonso Fasano *Department of Clinical Neuroscience, Neurosurgery, Karolinska Institute, Stockholm, Sweden.
Andres M Lozano *Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. lozano@uhnresearch.ca.

Funding

Functional Magnetic Resonance Imaging and Deep Learning to Improve Deep Brain Stimulation TherapyR01NS133433 · NINDS · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI Afis Ajala · 2023 to 2026
$1.7M
Michael J. Fox Foundation for Parkinson's Research MJFF-008877NIH HHS 1R01NS133433-01NINDS NIH HHS R01 NS133433
6 · The paper itself

Abstract

Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson's disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bilateral stimulation reinforces the recruitment of key motor hubs while reducing non-motor responses seen with unilateral stimulation and correlates with improved outcomes. This suggests a potential mechanistic basis for better motor function following bilateral stimulation.

Identifiers

PMID40676001
PMCPMC12271335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.