Evidence map›Paper›PMID 40675999›Full record

ArticleNPJ vaccines2025

Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines.

Milton Maciel, Lindsey R Baden, Brian Briney, Nicole A Doria-Rose, Kasalina N Kiwanuka, Shelly J Krebs, Angela Malaspina, Georgia D Tomaras, Andrew Ward, Gunilla B Karlsson Hedestam and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Milton MacielDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Lindsey R BadenBrigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Brian BrineyDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Nicole A Doria-RoseVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kasalina N KiwanukaDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Shelly J KrebsMilitary HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Angela MalaspinaDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Georgia D TomarasCenter for Human Systems Immunology, Duke Human Vaccine Institute, Departments of Surgery and Integrative Immunobiology, Duke University, Durham, NC, USA.
Andrew WardDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Gunilla B Karlsson HedestamDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Wilton B WilliamsDuke Human Vaccine Institute, Departments of Surgery and Integrative Immunobiology, Duke School of Medicine, Durham, NC, USA.
M Patricia D'SouzaDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. pdsouza@niaid.nih.gov.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
Harvard Medical School Vaccine Clinical Trials UnitUM1AI069412 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Lindsey Robert Baden, Daniel R. Kuritzkes · 2012 to 2026
$57.2M
Evaluation of Antibody Responses Elicited by Zika Vaccination in Flavivirus-naïve and -experienced IndividualsR01AI155983 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI Vincent Dussupt · 2021 to 2026
$4.2M
NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI155983NIAID NIH HHS UM1 AI069412
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40675999
PMCPMC12271457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.