ArticleAJNR. American journal of neuroradiology2025
Corticospinal Tract Displacement: A Novel Imaging Marker for Arm Recovery in Patients with Acute Hypertensive Intracerebral Hemorrhage.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Longitudinal automated fiber quantification reveals corticospinal tract dynamics and prognostic significance after primary basal ganglia hemorrhage.Neuroradiology · 2026Article
- Hematoma Coagulation is Associated with Perihematoma Edema Volume in Patients with Acute Intracerebral Hemorrhage.Neurocritical care · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeBrain parenchymal mass effect after acute intracerebral hemorrhage (ICH) causes neurologic deficits by displacing and or damaging the corticospinal tract (CST). The impact of corticospinal tract displacement (CSTD) on arm recovery and the influence of hematoma reversal on recovery are not well understood. We conducted a serial MRI study to explore these relationships. MATERIALS AND
methodsEighteen patients with spontaneous subcortical ICH were scanned on days 2 (baseline) and 90 (90 days) of onset. We used 3D-anatomic and 2D-DTI MRI, segmenting hematoma volume (HV), perihematomal edema (PHE), and the posterior limbs of the internal capsule (PLIC) volume labeled as native space. Presegmented PLIC volumes labeled as standard PLIC were obtained by using DTI-atlas. All segmented volumes were registered on a standard T1-weighted image followed by inverse-matrix transformation. Centroid-coordinates in native and standard PLIC were determined and a change in Euclidean distance was used to assess CSTD. Additionally, we measured changes in corticospinal tract volume due to lesion load (LLCSTV). ICH severity and upper extremity impairment were assessed by using NIHSS and Fugl-Meyer Upper Extremity (FM-UE) scores. A generalized linear mixed-model was applied to analyze CSTD and volume changes. A Bayesian inference was used to determine the posterior probability (PP). The CSTD, LLCSTV, and HV were correlated with NIHSS and FM-UE scores.
resultsWe enrolled 11 men and 7 women, with a mean age of 54.8 (standard deviation = 11.8). Analyses found strong support for temporal change in hematoma volume (14.8 ± 23.7 to 4.46 ± 4.99 mL) 75.5% decrease in log HV (
conclusionsWe present a quantitative surrogate imaging marker of CSTD and its association with arm recovery after ICH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.