ArticleeNeuro2025
The Use of Internal States to Guide Behavior Is Associated with Functional Engagement of the Anterior Insula in Male Rats.
Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interoception and associated subjective states shape adaptive behaviors. In humans, interoceptive information is hierarchically processed in the insular cortex (IC), being integrated first in the posterior IC (PIC) and then processed in the anterior IC (AIC) to generate subjective states. However, it has not been established whether this is the case in other species nor whether utilization of interoceptive states to guide behavior is also specifically associated with functional engagement of the AIC, as suggested by this hierarchical model. We investigated in male Sprague Dawley rats whether the use of pharmacologically induced internal states to guide instrumental behavior in a discrimination task functionally engages the AIC as opposed to the mere experience of such states. Rats trained to use the interoceptive state produced by the centrally acting GABA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.