ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2025
Double-Chambered Right Ventricle and Intraventricular Thrombosis Mimicking Double-Chambered Right Ventricle in Cynomolgus Monkeys (Macaca fascicularis).
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Reports of congenital heart disease in nonhuman primates are rare, and double-chambered right ventricle (DCRV), which is a rare congenital heart disease, in which an abnormal muscle bundle divides the right ventricle into 2 chambers (a proximal high-pressure chamber and a distal low-pressure chamber), has not been previously reported. We diagnosed DCRV antemortem in 2 monkeys bred at The Tsukuba Primate Research Center that presented with cardiac murmurs. Subsequent diagnostic evaluation confirmed DCRV in one case, with the other diagnosed with midventricular obstruction having a pathophysiology similar to DCRV. The monkey that had DCRV exhibited a pathophysiology similar to that in humans with DCRV, while the other monkey had a condition mimicking DCRV which was due to a thrombus. We believe this to be the first report of DCRV and a rare DCRV-like pathophysiology due to a thrombus in the ventricle in nonhuman primates.
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