ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2025
Rodent Pathogen Detection via Testing of Soiled Nesting Material.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine pathogens affect laboratory animal health and research outcomes, and the prevention of pathogen incursion or the elimination of pathogen outbreaks is paramount. To this end, sensitive methods for pathogen detection are continually being developed and improved. Environmental health monitoring has become a popular and sensitive method for pathogen detection. Published methods for environmental sampling include the collection and testing of exhaust air filters, exhaust air duct swabs, and swabs or filter media placement in empty cages with soiled bedding. Our study tested soiled, cotton nesting material (Nestlet™) in occupied cages for the detection of nucleic acid from certain, high-prevalence, murine pathogens. Nesting material from cages housing mice positive for mouse norovirus, Helicobacter spp., and Rodentibacter heylii consistently tested positive for these agents. In addition, nesting material from cages housing naïve mice to which soiled bedding from the infected cages was transferred tested positive for these agents more often than testing the mice directly. This study concluded that testing of particulate material (for example, dust) from soiled nesting material is a sensitive detection method for certain, high-prevalence murine pathogens.
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