ReviewJournal of advanced research2026
Organelle regulation of SUMOylation: regulatory mechanisms and therapeutic application.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Mimicking mammalian hibernation to lock cancer cells in safe quiescence.Discover oncology · 2026Article
- SUMOylation Inhibitor TAK-981 Alleviates Hallmark Features of Preeclampsia Related to High Glucocorticoid Exposure by Inhibiting Placental Oxidative Stress in Rats.Antioxidants (Basel, Switzerland) · 2026Article
- SUMOylation of UBE2C facilitates hepatocellular carcinoma proliferation and invasion via the MAPK pathway.Translational cancer research · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSUMOylation is a pivotal post-translational modification (PTM) that has been extensively investigated in nuclear processes. However, its role in regulating suborganelle homeostasis warrants further exploration. Recent studies have highlighted the significance of SUMOylation in modulating mitochondrial dynamics and endoplasmic reticulum stress (ERS), among other cellular processes, thereby offering novel insights into disease pathogenesis. AIM OF REVIEW: This review aims to systematically elucidate the roles and mechanisms of SUMOylation in regulating the homeostasis of various organelles. Furthermore, it integrates emerging evidence concerning the regulation of multi-organelle functions via SUMOylation and its associated PTM network. Additionally, it proposes novel therapeutic strategies targeting the SUMOylation pathway for diseases linked to these processes. KEY SCIENTIFIC CONCEPTS OF REVIEW: SUMOylation plays a pivotal role in regulating fundamental cellular processes, including mitochondrial function, ER protein folding, intracellular vesicle transport and degradation, ribosome assembly, and lipid droplet formation. By serving as a bridge for inter-organelle signal communication, SUMOylation coordinates cross-organelle stress responses and acts as a central regulatory hub for maintaining organelle homeostasis. Moreover, the intricate network formed by SUMOylation in conjunction with other PTMs, such as ubiquitination and phosphorylation, collaboratively regulates organelle states and functions as a critical molecular switch for controlling cellular protein homeostasis. Currently, targeted intervention strategies focusing on the SUMOylation pathway have emerged as a promising translational medicine research direction for restoring organelle homeostasis and addressing tumors and metabolic diseases, demonstrating broad clinical application potential.
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