Evidence map›Paper›PMID 40675227›Full record

ArticleBiochemical pharmacology2025

Angiotensin-(1-7) modulates gut-bone marrow axis in diabetes.

Kishore Chittimalli, Ishan Manandhar, Stephen Adkins, Manseb Rahman, Andrew Toelle, Ramakumar Tummala, Bina Joe, Yagna P R Jarajapu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kishore ChittimalliDepartment of Pharmaceutical Sciences, College of Health and Human Sciences, North Dakota State University, Fargo, ND 58105, USA.
Ishan ManandharMicrobiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Stephen AdkinsSchool of Biomedical Sciences, University of North Dakota, Grand Forks, ND, USA.
Manseb RahmanDepartment of Pharmaceutical Sciences, College of Health and Human Sciences, North Dakota State University, Fargo, ND 58105, USA; College of Arts & Sciences, University of North Dakota, Grand Forks, ND, USA.
Andrew ToelleDepartment of Pharmaceutical Sciences, College of Health and Human Sciences, North Dakota State University, Fargo, ND 58105, USA.
Ramakumar TummalaMicrobiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Bina JoeMicrobiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Yagna P R JarajapuDepartment of Pharmaceutical Sciences, College of Health and Human Sciences, North Dakota State University, Fargo, ND 58105, USA. Electronic address: Yagna.Jarajapu@ndsu.edu.

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
Targeting Mas Receptor for Diabetic Vascular Disease in Older AdultsR01AG056881 · NIA · NORTH DAKOTA STATE UNIVERSITY · PI Yagna Jarajapu · 2017 to 2026
$3.2M
NIA NIH HHS R01 AG056881NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

Diabetes promotes inflammation by compromising colon epithelial barrier integrity and upregulation of myelopoiesis in the bone marrow (BM). Angiotensin-(1-7) (Ang-(1-7)) is a cardiovascular protective peptide in diabetes. This study tested if Ang-(1-7) restores the colon epithelial barrier integrity and myelopoiesis in diabetes via restructuring dysbiotic gut microbiota and the BM-inflammatory landscape. Nondiabetic (ND) or streptozotocin-induced type 1 or db/db type 2 diabetic mice were treated with saline or Ang-(1-7). The intestinal permeability was evaluated by using FITC-dextran. Claudin1, occludin, Lgr5

Indexed as

Angiotensin IBone MarrowDiabetes Mellitus, ExperimentalGastrointestinal MicrobiomePeptide FragmentsAnimalsIntestinal MucosaMaleMiceMice, Inbred C57BLAngiotensin Iangiotensin I (1-7)Peptide FragmentsAngiotensin-(1–7)DiabetesGut MicrobiomeGut PermeabilityInflammationMyelopoiesis

Identifiers

PMID40675227
PMCPMC12315805

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.