ArticleDevelopmental cell2025
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube.
Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Gene regulatory innovations from transposable elements in primate cerebellum development.Nature communications · 2026Article
- Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization.Development (Cambridge, England) · 2026Article
- Stem cell-based approach to identify regulatory TFs during mammalian cell differentiation.Stem cell reports · 2025Article
- Article
- Decoding gene networks controlling hypothalamic and prethalamic neuron development.Cell reports · 2025Article
- Timing neural development and regeneration.Current opinion in neurobiology · 2025Review
- Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.bioRxiv : the preprint server for biology · 2025Article
- An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast.Development (Cambridge, England) · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organizing cell fate specification has been extensively studied, temporal patterning, which controls the timing of cell type generation, is equally important. Here, we define a global temporal program operating in progenitors throughout the mouse nervous systems that governs cell fate choices by controlling chromatin accessibility. Perturbation of this cis-regulatory program affects sequential cell fate transitions in neural progenitors and the identity of their progeny. The temporal program operates in parallel to spatial patterning, ensuring the timely availability of regulatory elements for spatial determinants to direct cell-type-specific gene expression. These findings identify a chronotopic spatiotemporal integration strategy in which a global temporal chromatin program determines the output of a spatial gene regulatory network resulting in the ordered allocation of cell type identity.
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Registered trials
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