Evidence map›Paper›PMID 40675151›Full record

ArticleCurrent biology : CB2025

Insulin signaling activity in the somatic gonad controls dauer entry via the germ line in C. elegans.

Grace E Przybyl, Julia Wittes, Iva Greenwald

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Grace E PrzybylDepartment of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA.
Julia WittesDepartment of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA.
Iva GreenwaldDepartment of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA. Electronic address: isg4@columbia.edu.

Funding

Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Regulatory Circuitry and Mechanisms Controlling Cell Fate in C. elegansR35GM131746 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Iva S Greenwald · 2019 to 2026
$5.0M
Regulation of blast cell quiescence by Pten and TorF32GM140732 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI WITTES, JULIA SARAH · 2021 to 2022
$136k
NIDDK NIH HHS T32 DK007328NIGMS NIH HHS F32 GM140732NIGMS NIH HHS R35 GM131746NIH HHS P40 OD010440
6 · The paper itself

Abstract

C. elegans displays remarkable developmental plasticity in response to environmental conditions.

Indexed as

Caenorhabditis elegansGerm CellsInsulinSignal TransductionAnimalsCaenorhabditis elegans ProteinsDiapauseGonadsLarvaReceptor, InsulinCaenorhabditis elegans ProteinsDAF-2 protein, C elegansInsulinReceptor, InsulinAIDAKTC. elegansdaf-16daf-2dauerdiapausegermlinegonadinsulin signaling

Identifiers

PMID40675151
PMCPMC12747165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.