Evidence map›Paper›PMID 40675148›Full record

ArticleCell2025

Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals.

Simon Haziza, Radosław Chrapkiewicz, Yanping Zhang, Vasily Kruzhilin, Jane Li, Jizhou Li, Geoffroy Delamare, Rachel Swanson, György Buzsáki, Madhuvanthi Kannan and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Causal and directional elements of global brain dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  5. Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Simon HazizaJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: sihaziza@stanford.edu.
Radosław ChrapkiewiczJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
Yanping ZhangJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Vasily KruzhilinJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Jane LiJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
Jizhou LiCNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
Geoffroy DelamareCNC Program, Stanford University, Stanford, CA 94305, USA.
Rachel SwansonNeuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, USA.
György BuzsákiNeuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, USA; Department of Neurology, Langone Medical Center, New York University, New York, NY 10016, USA.
Madhuvanthi KannanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Ganesh VasanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Michael Z LinDepartments of Bioengineering & Neurobiology, Stanford University, Stanford, CA 94305, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA 98109, USA.
Mark J SchnitzerJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: mschnitz@stanford.edu.

Funding

Traveling Waves in Neocortical Circuits: Mechanisms, Computational Roles in Sensory Processing, and Impact on Sensory PerceptionU01NS131914 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI COLEMAN, TODD P, KUZUM, DUYGU · 2023 to 2025
$6.0M
Multi-color optical voltage imaging of neural activity in behaving animalsU01NS120822 · NINDS · STANFORD UNIVERSITY · PI SCHNITZER, MARK J, VASAN, GANESH · 2021 to 2025
$3.3M
Dissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-typesR01NS124590 · NINDS · STANFORD UNIVERSITY · PI MARK J SCHNITZER, IVAN SOLTESZ · 2021 to 2026
$3.1M
Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivoU01NS103464 · NINDS · STANFORD UNIVERSITY · PI DIEUDONNE, STEPHANE, LIN, MICHAEL Z. · 2017 to 2019
$2.9M
Transgenic mice and multiplexed, multi-beam instrumentation for large-scale optical experiments on brain states and ensemble cellular dynamics in behaving animalsUF1NS107610 · NINDS · STANFORD UNIVERSITY · PI SCHNITZER, MARK J, ZENG, HONGKUI · 2018 to 2018
$2.9M
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
NIH HHS S10 OD010580NINDS NIH HHS R01 NS124590NINDS NIH HHS U01 NS103464NINDS NIH HHS U01 NS120822NINDS NIH HHS U01 NS131914NINDS NIH HHS UF1 NS107610
6 · The paper itself

Abstract

Fluorescent genetically encoded voltage indicators report transmembrane potentials of targeted cell types. However, voltage-imaging instrumentation has lacked the sensitivity to track spontaneous or evoked high-frequency voltage oscillations in neural populations. Here, we describe two complementary TEMPO (transmembrane electrical measurements performed optically) voltage-sensing technologies that capture neural oscillations up to ∼100 Hz. Fiber-optic TEMPO achieves ∼10-fold greater sensitivity than prior photometric voltage sensing, allows hour-long recordings, and monitors two neuron classes per fiber-optic probe in freely moving mice. With it, we uncovered cross-frequency-coupled theta- and gamma-range oscillations and characterized excitatory-inhibitory neural dynamics during hippocampal ripples and visual cortical processing. The TEMPO mesoscope images voltage activity in two cell classes across an ∼8-mm-wide field of view in head-fixed animals. In awake mice, it revealed sensory-evoked excitatory-inhibitory neural interactions and traveling gamma and 3-7 Hz waves in visual cortex and bidirectional propagation directions for both hippocampal theta and beta waves. These technologies have widespread applications probing diverse oscillations and neuron-type interactions in healthy and diseased brains.

Indexed as

NeuronsAnimalsHippocampusMaleMembrane PotentialsMiceMice, Inbred C57BLVisual Cortexbeta oscillationsfluorescence imaginggamma oscillationslocal field potentialsneural dynamicssharp wave ripplestheta oscillationsvoltage imagingvoltage indicatorsvoltage waves

Identifiers

PMID40675148
PMCPMC12616578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.