Evidence map›Paper›PMID 40674729›Full record

ReviewAnnual review of genetics2025

Cell Death, Compensatory Proliferation, and Cell Competition.

Andreas Bergmann

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Andreas BergmannDepartment of Molecular, Cell and Cancer Biology, UMass Chan Medical School, Worcester, Massachusetts, USA; email: andreas.bergmann@umassmed.edu.

Funding

Mechanisms and consequences of programmed cell death (apoptosis) and compensatory proliferation in DrosophilaR35GM118330 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BERGMANN, ANDREAS · 2016 to 2025
$6.5M
NIGMS NIH HHS R35 GM118330
6 · The paper itself

Abstract

Cell death, compensatory proliferation, and cell competition are fundamental interconnected processes that shape how tissues develop, maintain homeostasis, and regenerate. In this review, I highlight how cell death (apoptosis) not only eliminates excess and damaged cells but can also initiate compensatory proliferation, an adaptive response that occurs following cell loss. I examine cell competition, a quality-control mechanism that removes less fit loser cells in favor of healthier winner neighbors. Cell competition is intricately linked to cell death and compensatory proliferation. I present the history of these processes, discuss the most important examples, and reveal the key molecular mechanisms that underlie them. I incorporate findings from

Indexed as

ApoptosisCell CompetitionCell DeathCell ProliferationAnimalsCaenorhabditis elegansDrosophila melanogasterHomeostasisHumansNeoplasmsSignal Transductionapoptosisapoptosis-induced proliferationcaspasescell competitioncompensatory proliferationDrosophila

Identifiers

PMID40674729
PMCPMC12810938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.