ArticleMagnetic resonance in medicine2025
Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.Magnetic resonance in medicine · 2026Article
- Human Brain High-Resolution Diffusion MRI With Optimized, Slice-By-Slice, Zeroth and First OrderMagnetic resonance in medicine · 2026Article
- Strong-Gradient Diffusion-Weighted Imaging of Prostate Cancer Using an Inside-Out Nonlinear Gradient Coil.Magnetic resonance in medicine · 2026Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
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4 authors.
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Abstract
purposeTo investigate the time and frequency dependence of diffusion kurtosis in the in vivo human brain with pulsed (PGSE) and oscillating gradient spin-echo (OGSE) experiments over a range of diffusion times and frequencies using high-performance gradients.
methodsFour OGSE waveforms probing centroid frequencies of 11, 20, 34, and 51 Hz, corresponding to equivalent effective diffusion times of 22.7, 12.5, 7.4, and 4.9 ms; and three PGSE waveforms probing effective diffusion times of 50, 22.7, and 12.5 ms were designed for experimentation. Seven healthy volunteers were scanned using said waveforms at b-values of 500, 1000, and 2000 s/mm
resultsNon-monotonic, biphasic kurtosis time- and frequency-dependences were observed in different white and gray matter regions. This behavior supports the notion that kurtosis is influenced by the combined effects of water-restriction interactions, inter-compartmental water exchange, and tissue heterogeneity. Kurtosis values measured using OGSE and PGSE waveforms at the same effective diffusion times showed significant discrepancies, with consistently higher values from PGSE than OGSE. These discrepancies are mainly attributed to differences in exchange sensitivities among gradient waveforms based on analogous findings from Monte-Carlo simulations.
conclusionKurtosis was found to exhibit biphasic time- and frequency-dependence in the human brain. When interpreting kurtosis measurements, the influence of exchange sensitivities of employed gradient waveforms should be considered.
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