Evidence map›Paper›PMID 40674622›Full record

ArticleMagnetic resonance in medicine2025

Simultaneous zero echo time fMRI of rat brain and spinal cord.

Hanne Laakso, Lin Wu, Sara Ponticorvo, Raimo A Salo, Jaakko Paasonen, Ekaterina Paasonen, Mikko Kettunen, Russell L Lagore, Lance DeLabarre, Ethan Polcyn and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Magnetic resonance imaging.Science advances · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Hanne LaaksoA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0003-1142-9008
Lin WuCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Sara PonticorvoCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Raimo A SaloA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Jaakko PaasonenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Ekaterina PaasonenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0003-2365-865X
Mikko KettunenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Russell L LagoreCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-1950-1828
Lance DeLabarreCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Ethan PolcynCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Gregor AdrianyCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-6428-9005
Javier IstúrizNeos Biotec, Pamplona, Spain.
Dee M KoskiCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Djaudat IdiyatullinCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-0942-3208
Olli GröhnA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Silvia MangiaCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-6341-4516
Shalom MichaeliCenter for Magnetic Resonance Research, Deptartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Obtaining brain pCO2, pH and pO2 maps via measurements of neurovascular coupling: a novel non-invasive approach to identify the culprits of loss of brain functionDP1AG093028 · NIA · UNIVERSITY OF MINNESOTA · PI Silvia Mangia · 2024 to 2026
$3.2M
MB-SWIFT as a novel approach for simultaneous functional imaging of the brain and spinal cordR01NS129739 · NINDS · UNIVERSITY OF MINNESOTA · PI Olli Grohn, SHALOM MICHAELI · 2023 to 2026
$1.9M
Console Replacement and Upgrade of 9.4 Tesla Animal InstrumentS10OD032192 · OD · UNIVERSITY OF MINNESOTA · PI CHEN, WEI · 2022 to 2022
$1.3M
NIA NIH HHS DP1 AG093028NIBIB NIH HHS P41 EB027061NIH HHS DP1AG093028NIH HHS P41 EB027061NIH HHS R01NS129739NIH HHS S10 OD032192NINDS NIH HHS R01 NS129739Research Council of Finland 331955Research Council of Finland 358944Research Council of Finland 371485W.M. Keck Foundation
6 · The paper itself

Abstract

purposeFunctional assessments of the central nervous system (CNS) are essential for many areas of research. fMRI typically targets either the brain or the spinal cord, but usually not both, because of the obstacles associated with simultaneous image acquisitions from distant fields of view (FOVs) with conventional MRI. In this work, we establish a novel MRI approach that enables artifact-free, quiet, simultaneous fMRI of both brain and spinal cord, avoiding the need for dynamic shimming procedures.

methodsWe used zero TE Multi-Band-SWeep Imaging with Fourier Transformation (MB-SWIFT) technique at 9.4 T in a simultaneous dual-FOV configuration and two separate RF transmit-receive surface coils. The first coil covered the rat brain, while the second was positioned approximately at the T13-L1 level of the rat's spinal cord with copper shielding to minimize the coupling between the RF coils. Eight Sprague-Dawley rats were used for hindlimb stimulation fMRI studies.

resultsRobust and specific activations were detected in both the brain and spinal cord during hindlimb stimulation at individual and group levels. The results established the feasibility of the novel approach for simultaneous functional assessment of the lumbar spinal cord and brain in rats.

conclusionThis study demonstrated the feasibility of a novel dual-FOV fMRI approach based on zero-TE MB-SWIFT and set the stage for translation to humans. The methodology enables comprehensive functional CNS evaluations of great value in different conditions such as pain, spinal cord injury, neurodegenerative diseases, and aging.

Indexed as

BrainMagnetic Resonance ImagingSpinal CordAnimalsMaleRatsRats, Sprague-DawleyReproducibility of Resultsbrain fMRIdual‐FOVMB‐SWIFTsimultaneous acquisitionspinal cord fMRIzero‐TE

Identifiers

PMID40674622
PMCPMC12283057

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.