Evidence map›Paper›PMID 40674576›Full record

Observational studyInterdisciplinary cardiovascular and thoracic surgery2025

Outcomes following extended thoracic endovascular aortic repair for Type B aortic dissection from the global registry for endovascular aortic treatment.

Sara Allievi, Tim J Mandigers, Fred A Weaver, Ali Azizzadeh, Gabriele Piffaretti, Marc L Schermerhorn, Gregory A Magee, Dennis R Gable, Chiara Lomazzi, Santi Trimarchi

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Descending Thoracic Aortic Diameter Is a Predictor of Poor Outcome After Endovascular Aortic Repair.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026
    Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara AllieviSection of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0003-4428-9494
Tim J MandigersSection of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-9508-4088
Fred A WeaverDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ali AzizzadehDivision of Vascular Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-6734-4903
Gabriele PiffarettiVascular Surgery, Department of Medicine and Surgery, University of Insubria School of Medicine, Varese, Italy.ORCID 0000-0002-9906-4658
Marc L SchermerhornDivision of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4278-964X
Gregory A MageeDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9008-6642
Dennis R GableDivision of Vascular and Endovascular Surgery, Baylor Scott & White Heart Hospital, Plano, TX, USA.ORCID 0000-0002-6847-2587
Chiara LomazziSection of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0003-0172-1291
Santi TrimarchiSection of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0001-5996-3264

Funding

Global Registry for Endovascular Aortic Treatment
6 · The paper itself

Abstract

objectivesThis study evaluated the short- to longer-term safety and efficacy of extended thoracic endovascular aortic repair for Type B aortic dissection.

methodsWe identified acute and subacute Type B dissection between 2010 and 2016 in the Global Registry for Endovascular Aortic Treatment. We stratified the population based on treatment extent: 'non-extended' (1 stent graft deployed), 'extended' (>1 stent graft deployed). Our primary outcomes were in-hospital spinal cord ischaemia and mortality. Secondarily, we evaluated procedure-related complications (endoleak, migration, fracture, compression, reinterventions), sac dynamics, rupture, and all-cause mortality at 1 and 5 years. Sensitivity analysis was performed in patients without prior aortic procedures.

resultsOf 170 procedures, 78 (46%) were extended (median 2 [range 2-5] stent-grafts). Extended and non-extended treatment had similar rates of complicated presentations (53% vs 64%; P = 0.13). Compared with non-extended treatment, extended treatment had similar in-hospital rates of spinal cord ischaemia (2.6% vs 2.2%; P = 1) and mortality (2.6% vs 2.2%, P = 1). Additionally, extended treatment had not statistically different sac expansion rates, (1 year: 14% vs 23%, P =0.80; 5 years: 16% vs 32%, P=0.29) and rupture risk (1 year: 1.3% vs 3.3%, P = 0.63), similar procedure-related complications (endoleak, migration, fracture, compression, reinterventions; all P > 0.05) and all-cause mortality (1 year: 10% vs 7.6%, P=0.54; 5 years: 19% vs 21%, P=0.82). All outcomes remained similar on sensitivity analysis.

conclusionsOur findings suggest that extended treatment for Type B aortic dissection may be associated with similar procedure-related risks and complications. Future larger studies are needed to define who might benefit from an extended treatment and further optimize patient-specific treatment for aortic dissection.

Indexed as

Aortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationEndovascular ProceduresAgedBlood Vessel ProsthesisEndovascular Aneurysm RepairFemaleHospital MortalityHumansMaleMiddle AgedPostoperative ComplicationsRegistriesRetrospective StudiesRisk FactorsGREAT registrylong-term outcomessac dynamicsspinal cord ischaemiathoracic endovascular aortic repairType B aortic dissection

Identifiers

PMID40674576
PMCPMC12282756

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.