ArticleJBRA assisted reproduction2025
Prediction of human embryo ploidy based on morphokinetic parameters: Investigating the use of time-lapse imaging for non-invasive embryo selection.
Article in JBRA assisted reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Analysis of morphological, morphokinetics, cell-free DNA, microRNAs parameters to predict aneuploidy status of embryos.PloS one · 2026Article
- Ploidy and Implantation Potential: Non-Invasive Small Non-Coding RNA-Based Health Assessment of Day 5 and 6 Blastocysts.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
objectiveTo evaluate the relationship between time-lapse (TL) imaging parameters and the ploidy of human blastocysts.
methodsThis observational study retrospectively analyzes time-lapse images from 84 blastocysts tested for aneuploidies, focusing on morphokinetic evaluation based on cell division (st2, t2, t3, t4, t5, t8, tSC) and blastocyst formation parameters (tSB, tB).
resultsAmong the TL parameters, t5, t2-st2, cc3 (t5-t3), t5-t2, s3 (t8-t5), and tB-tSB showed a significant association with ploidy, being shorter for euploid blastocysts. The respective median times/intervals for euploid and aneuploid embryos were as follows: t5, 46.5 vs. 49.6 (p=0.015); t2-st2, 2.5 vs. 2.25 (p=0.0236); cc3, 11.7 vs. 13.3 (p=0.046); t5-t2, 22.1 vs. 24.4 (p=0.0185); s3, 10.9 vs. 3.3 (p=0.019); and tB-tSB, 7.6 vs. 9.9 (p=0.0084). ROC curves identified a moderate predictive ability of the parameters to discern euploid embryos. Additionally, initial cytoplasmic movements prior to the first cell cleavage were noted; pattern 1 (vibration-like movements), pattern 2 (circular wave movements), or pattern 0 (the absence of detectable movements) were not significantly correlated with ploidy.
conclusionsEuploid blastocysts reach certain cell division stages (t5, t5-t3, t5-t2, t8-t5) and blastocyst formation stages (tB-tSB) more quickly than aneuploid ones. If further studies confirm this, our results should serve as criteria for selecting embryos to be biopsied, potentially avoiding the procedure when euploidy can be predicted from morphokinetic features.
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