Evidence map›Paper›PMID 40674426›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

An enzyme-based approach for highly efficient self-replication of DNA origami dimers.

Lei Zhang, Ruojie Sha, Paul Chaikin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Dynamic Control of DNA Origami Self-Assembly by Transcriptional Modules.Journal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lei ZhangDepartment of Physics, New York University, New York, NY 10003.ORCID 0000-0002-1673-5816
Ruojie ShaDepartment of Chemistry, New York University, New York, NY 10003.ORCID 0000-0002-0807-734X
Paul ChaikinDepartment of Physics, New York University, New York, NY 10003.ORCID 0000-0001-9864-0089

Funding

DOE | SC | Basic Energy Sciences (BES) De-SC0007991
6 · The paper itself

Abstract

Self-replication and exponential growth are essential to all living things, the driving force for Darwinian evolution, and potentially useful in nanotechnology for large-scale production of nanoscopic materials. An artificial (nonliving) self-replication system has been shown to exhibit exponential growth and selection using DNA monomer origami tiles templated on a dimer seed. That system purposefully avoided the use of enzymes to get a hint of how self-replication might have evolved in a prebiotic world by using

Indexed as

DNADNA LigasesDNA ReplicationDimerizationNanotechnologyNucleic Acid ConformationDNADNA Ligasesdarwinian evolutionDNA origami tilesexponential growthligationself-replication

Identifiers

PMID40674426
PMCPMC12304977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.